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Immune Regulation News

DNA of Neutrophil Extracellular Traps Promotes Cancer Metastasis via CCDC25

[Nature] Investigators showed that neutrophil extracellular traps (NETs) were abundant in the liver metastases of patients with breast and colon cancers, and that serum NETs could predict the occurrence of liver metastases in patients with early-stage breast cancer.

A Variant in IL6ST with a Selective IL-11 Signaling Defect in Human and Mouse

[Bone Research] Researchers characterized the impact of a variant on cytokine signaling in vitro using transfected cell lines as well as primary patient-derived cells and supported these findings using a mouse model with the corresponding genome-edited variant Il6st p.R279Q.

convertibleCARs: A Chimeric Antigen Receptor System for Flexible Control of Activity and Antigen Targeting

[Communications Biology] An inert form of the human NKG2D extracellular domain (iNKG2D) was engineered as the ectodomain of the chimeric antigen receptor (CAR) to generate convertibleCARTM-T cells. These cells were specifically directed to kill antigen-expressing target cells only in the presence of an activating bispecific adapter comprised of an iNKG2D-exclusive ULBP2-based ligand fused to an antigen-targeting antibody

The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

[Cell] Investigators summarize and question what is known and remains to be discovered about the TREM2 signaling pathway, track the consequences of its activation in physiological niches and pathological contexts, and highlight the promising potential of therapeutic manipulation of TREM2 signaling.

Old Dogs, New Trick: Classic Cancer Therapies Activate cGAS

[Cell Research] The authors review the antitumor roles of the GMP-AMP synthase (cGAS-STING) pathway during tumorigenesis, cancer immune surveillance, and cancer therapies. They also highlight classic cancer therapies that elicit antitumor immune responses through cGAS activation.

Pro-Lymphangiogenic VEGFR-3 Signaling Modulates Memory T Cell Responses in Allergic Airway Inflammation

[Mucosal Immunology] Researchers explored how pro-lymphangiogenic signaling affects the allergic response to house dust mite. In the acute inflammatory phase, the lungs of mice treated with blocking antibodies against VEGFR-3 displayed less inflammation overall, with dramatically reduced innate and T-cell numbers and reduced inflammatory chemokine levels.

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