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Immunology of Infectious Disease News
Immunology of Infectious Disease News
Pre-Existing Immunity to Influenza Virus Hemagglutinin Stalk Might Drive Selection for Antibody-Escape Mutant Viruses in a Human Challenge Model
[Nature Medicine] Researchers showed that immune pressure on the hemagglutinin (HA) stalk could lead to expansion of escape mutant viruses in study participants challenged with a 2009 H1N1 pandemic influenza virus inoculum containing an A388V polymorphism in the HA stalk
Immunology of Infectious Disease News
Mucus Layer Modeling of Human Colonoids during Infection with Enteroaggragative E. coli
[Scientific Reports] Investigators used human colonoids comprising goblet cells and a thick mucin barrier as an intestinal model to investigate Pic’s roles during infection with EAEC.
Immune Regulation News
Extracellular Glucose Is Crucially Involved in the Fate Decision of LPS-Stimulated RAW264.7 Murine Macrophage Cells
[Scientific Reports] The authors showed that lipopolysaccharide (LPS) stimulation of RAW264.7 murine macrophage celled results in pyroptosis when cells were cultured in high glucose medium.
Endothelial Cell News
The Vascular Endothelium: The Cornerstone of Organ Dysfunction in Severe SARS-CoV-2 Infection
[Critical Care] Venous thrombotic events, particularly pulmonary embolism, with elevated D-dimer and coagulation activation are highly prevalent in COVID-19 patients. The pro-inflammatory cytokine storm, with elevated levels of interleukin-6 (IL-6), IL-2 receptor, and tumor necrosis factor-α, could also participate in endothelial dysfunction and leukocyte recruitment in the microvasculature.
Immunology of Infectious Disease News
Mesenchymal Stem Cells Offer a Drug-Tolerant and Immune-Privileged Niche to Mycobacterium tuberculosis
[Nature Communications] Investigators report that mesenchymal stem cells (MSCs) sheltered Mybacterium tuberculosis (Mtb) to help tolerate anti-TB drugs. MSCs readily took up Mtb and allowed unabated mycobacterial growth despite having a functional innate pathway of phagosome maturation.
Human Immunology News
CRISPR-Cas9 Mediated Glucocorticoid Resistance in Virus-Specific T Cells for Adoptive T-Cell Therapy Post Transplantation
[Molecular Therapy] In order to deliver protection against viral pathogens and allow at the same time necessary steroid therapy, scientists generated glucocorticoid-resistant T cells by CRISPR/Cas9-mediated knockout of the glucocorticoid receptor in primary human virus-specific T-cell products.