in silico

[Journal of Experimental & Clinical Cancer Research] Bioinformatic analysis, quantitative mRNA and protein expression analysis, cell models of sarcoma by ectopic expression ofEMX genes. Researchers measured tumorigenesis and populations enriched on stem cell phenotypes, either in vitro or in vivo.

[Inflammatory Bowel Diseases] Investigators profiled a panel of 39 genes potentially involved in cancer predisposition and searched for germline variants in IBD patients with colorectal cancer or high-grade dysplasia.

[Bioorganic Chemistry] Synthesized compounds were evaluated for their in vitro anticancer activity against various human cancer cell lines, including breast and prostate.

[Journal of Antibiotics] From the natural product screening, the novel compound arabilin was isolated from Streptomyces sp. MK756-CF1. Unlike STK765173, arabilin could overcome resistance to enzalutamide.

[Journal of Medicinal Chemistry] Researchers showed the efficacy of their most potent inhibitors in activating the antitumor response using primary human immune cells from healthy donors.

[Scientific Reports] After selecting miRNAs for the diagnosis of nonalcoholic steatohepatitis, scientists analyzed the diagnostic accuracy of each miRNA and the combination of miRNAs.