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in silico

CD97 Is Associated with Mitogenic Pathway Activation, Metabolic Reprogramming, and Immune Microenvironment Changes in Glioblastoma

[Scientific Reports] Using in silico and in vitro techniques, investigators demonstrated heterogeneous expression of CD97, a leukocyte adhesion marker, in human glioblastoma.

Enzymatic Activity of Glycosyltransferase GLT8D1 Promotes Human Glioblastoma Cell Migration

[iScience] Analysis of glioblastoma patient cohorts revealed a significant higher expression of Glycosyltransferase 8 domain containing 1 (GLT8D1) compared to normal brain tissue and could be associated with impaired patient survival.

Decursin Prevents Melanogenesis by Suppressing MITF Expression through the Regulation of PKA/CREB, MAPKs, and PI3K/Akt/GSK-3β Cascades

[Biomedicine & Pharmacotherapy] Decursin exhibited no cytotoxicity and significantly reduced intracellular tyrosinase activity and melanin content in B16F10 melanoma cells.

Urine Peptidome in Combination with Transcriptomics Analysis Highlights MMP7, MMP14 and PCSK5 for Further Investigation in Chronic Kidney Disease

[PLoS One] Through investigating chronic kidney disease-associated transcriptomics datasets, several proteases were highlighted including members of matrix metalloproteinases and serine proteases.

MiR-423-5p Prevents MALAT1-Mediated Proliferation and Metastasis in Prostate Cancer

[Journal of Experimental & Clinical Cancer Research] Using lentiviral stable miRNA transfection together with cell biology functional assays and gene expression/target analysis, scientists investigated the interaction between MALAT1 and miR-423-5p, defined as a target with in silico prediction analysis, in prostate cancer.

Methylation-Mediated Silencing of Protein Kinase C Zeta Induces Apoptosis Avoidance through ATM/CHK2 Inactivation in Dedifferentiated Chondrosarcoma

[British Journal of Cancer] Researchers identified genes downregulated in dedifferentiated chondrosarcoma vs. conventional chondrosarcoma due to DNA methylation using in silico analysis.

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