UBE2T Promotes Radiation Resistance in Non-Small Cell Lung Cancer via Inducing Epithelial-Mesenchymal Transition and the Ubiquitination-Mediated FOXO1 Degradation

Using bioinformatic analyses, researchers found that UBE2T was associated with survival, tumor size, lymph node metastasis and distant metastasis. They used colony formation, EdU incorporation, scratch, transwell assays, flow cytometry, immunofluorescence and western blot to assess the role of UBE2T in vitro and in vivo.
[Cancer Letters]

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Soluble Vegfr3 Gene Therapy Suppresses Multi‐Organ Metastasis in a Mouse Mammary Cancer Model

Scientists showed that psVEGFR‐3 significantly diminished cell growth with and without added VEGF‐C in vitro, and significantly reduced primary tumor growth and tumor metastases to wide‐spectrum organs in vivo.
[Cancer Science]
Shibata, M.-A., Shibata, E., Tanaka, Y., Shiraoka, C., & Kondo, Y. (n.d.). Soluble Vegfr3 gene therapy suppresses multi-organ metastasis in a mouse mammary cancer model. Cancer Science, n/a(n/a). https://doi.org/10.1111/cas.14531 Cite
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Emerging Routes to the Generation of Functional β-Cells for Diabetes Mellitus Cell Therapy

Substantial advances have been made in producing mature β-cells from human pluripotent stem cells that respond appropriately to dynamic changes in glucose concentrations in vitro and rapidly function in vivo following transplantation in mice.
[Nature Reviews Endocrinology]
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The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease

Treatment with either of two bone morphogenetic protein (BMP) inhibitors reduced hepatic triglyceride content in diabetic mice. BMP inhibitor-induced decrease in hepatic triglyceride levels was associated with decreased mRNA encoding Dgat2, an enzyme integral to triglyceride synthesis.
[Scientific Reports]
Thayer, T. E., Lino Cardenas, C. L., Martyn, T., Nicholson, C. J., Traeger, L., Wunderer, F., Slocum, C., Sigurslid, H., Shakartzi, H. R., O’Rourke, C., Shelton, G., Buswell, M. D., Barnes, H., Neitzel, L. R., Ledsky, C. D., Li, J. P., Burke, M. F., Farber-Eger, E., Perrien, D. S., … Malhotra, R. (2020). The Role of Bone Morphogenetic Protein Signaling in Non-Alcoholic Fatty Liver Disease. Scientific Reports, 10(1), 9831. https://doi.org/10.1038/s41598-020-66770-8 Cite
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PD173074 Blocks G1/S Transition via CUL3-Mediated Ubiquitin Protease in HepG2 and Hep3B Cells

Researchers found fibroblast growth factor receptor 4 (FGFR4) was overexpressed in hepatocellular carcinoma cell lines HepG2 and Hep3B. They used PD173074, an FGFR4 inhibitor, to explore the role of FGFR4 and its underlying mechanism in these cell lines.
[PLoS One]
Qiao, C., Qian, H., Wang, J., Zhao, T., Ma, P., Wang, S., Zhang, T., & Liu, X. (2020). PD173074 blocks G1/S transition via CUL3-mediated ubiquitin protease in HepG2 and Hep3B cells. PLOS ONE, 15(6), e0234708. https://doi.org/10.1371/journal.pone.0234708 Cite
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Cytochrome P450 1B1 Polymorphism Drives Cancer Cell Stemness and Patient Outcome in Head-and-Neck Carcinoma

From head-and-neck squamous cell carcinoma cell lines not expressing CYP1B1, investigators generated isogenic derivatives expressing the two forms. Proliferation, invasiveness, stem cell characteristics, sensitivity to anticancer agents and transcriptome were analyzed.
[British Journal of Cancer]
Morvan, V. L., Richard, É., Cadars, M., Fessart, D., Broca-Brisson, L., Auzanneau, C., Pasquies, A., Modesto, A., Lusque, A., Mathoulin-Pélissier, S., Lansiaux, A., & Robert, J. (2020). Cytochrome P450 1B1 polymorphism drives cancer cell stemness and patient outcome in head-and-neck carcinoma. British Journal of Cancer, 1–13. https://doi.org/10.1038/s41416-020-0932-5 Cite
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Bone Regeneration Capacities of Alveolar Bone Mesenchymal Stem Cells Sheet in Rabbit Calvarial Bone Defect

Scientists compared the osteogenic differentiation and bone defect repairment characteristics of bone marrow mesenchymal stem cells sheets derived from alveolar bone and iliac bone in vitro and in vivo.
[Journal of Tissue Engineering]
Liu, Y., Wang, H., Dou, H., Tian, B., Li, L., Jin, L., Zhang, Z., & Hu, L. (2020). Bone regeneration capacities of alveolar bone mesenchymal stem cells sheet in rabbit calvarial bone defect: Journal of Tissue Engineering. https://doi.org/10.1177/2041731420930379 Cite
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Protective Effect of a Fucose-Rich Fucoidan Isolated from Saccharina japonica against Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish

A fucose-rich fucoidan was purified from brown seaweed Saccharina japonica, of which the UVB protective effect was investigated in vitro in keratinocytes of HaCaT cells and in vivo in zebrafish. The intracellular ROS levels and the viability of UVB-irradiated HaCaT cells were determined.
[Marine Drugs]
Su, W., Wang, L., Fu, X., Ni, L., Duan, D., Xu, J., & Gao, X. (2020). Protective Effect of a Fucose-Rich Fucoidan Isolated from Saccharina japonica against Ultraviolet B-Induced Photodamage In Vitro in Human Keratinocytes and In Vivo in Zebrafish. Marine Drugs, 18(6), 316. https://doi.org/10.3390/md18060316 Cite
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Disseminated Melanoma Cells Transdifferentiate into Endothelial Cells in Intravascular Niches at Metastatic Sites

Researchers combined lineage tracing in a spontaneous metastatic mouse model of melanoma, advanced imaging, and single-cell RNA sequencing approaches to search for pathophysiologically relevant melanoma cellular states.
[Cell Reports]
Li, X., Karras, P., Torres, R., Rambow, F., Oord, J. van den, Marine, J.-C., & Kos, L. (2020). Disseminated Melanoma Cells Transdifferentiate into Endothelial Cells in Intravascular Niches at Metastatic Sites. Cell Reports, 31(11). https://doi.org/10.1016/j.celrep.2020.107765 Cite
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miR-410 Induces Both Epithelial-Mesenchymal Transition and Radioresistance through Activation of the PI3K/mTOR Pathway in Non-Small Cell Lung Cancer

Scientists demonstrated that PTEN was a direct target of miR-410 by using bioinformatic tools and dual-luciferase reporter assays, and the miR-410-induced epithelial–mesenchymal transition and radioresistance were reversed by PI3K, Akt, and mTOR inhibitors or by restoring the expression of PTEN in non-small cell lung cancer cells.
[Signal Transduction and Targeted Therapy]
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Organoid Models for Mammary Gland Dynamics and Breast Cancer

The authors summarized key aspects of mammary gland biology and corresponding organoid models. The investigators also discussed emerging applications where organoids will be transformative for studying both the biology and diseases of the breast.
[Current Opinion in Cell Biology]
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