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in vivo

UBE2T Promotes Radiation Resistance in Non-Small Cell Lung Cancer via Inducing Epithelial-Mesenchymal Transition and the Ubiquitination-Mediated FOXO1 Degradation

[Cancer Letters] Using bioinformatic analyses, researchers found that UBE2T was associated with survival, tumor size, lymph node metastasis and distant metastasis. They used colony formation, EdU incorporation, scratch, transwell assays, flow cytometry, immunofluorescence and western blot to assess the role of UBE2T in vitro and in vivo.

AAV8 Ins1-Cre can Produce Efficient β-Cell Recombination but Requires Consideration of Off-Target Effects

[Scientific Reports] Intraperitoneal AAV8 Ins1-Cre produced efficient β-cell recombination, alongside some hepatic, exocrine pancreas, α-cell, δ-cell, and hypothalamic recombination. Delivery of lower doses via the pancreatic duct retained good rates of β-cell recombination and limited rates of off-target recombination.

Soluble Vegfr3 Gene Therapy Suppresses Multi‐Organ Metastasis in a Mouse Mammary Cancer Model

[Cancer Science] Scientists showed that psVEGFR‐3 significantly diminished cell growth with and without added VEGF‐C in vitro, and significantly reduced primary tumor growth and tumor metastases to wide‐spectrum organs in vivo.

Emerging Routes to the Generation of Functional β-Cells for Diabetes Mellitus Cell Therapy

[Nature Reviews Endocrinology] Substantial advances have been made in producing mature β-cells from human pluripotent stem cells that respond appropriately to dynamic changes in glucose concentrations in vitro and rapidly function in vivo following transplantation in mice.

Cytochrome P450 1B1 Polymorphism Drives Cancer Cell Stemness and Patient Outcome in Head-and-Neck Carcinoma

[British Journal of Cancer] From head-and-neck squamous cell carcinoma cell lines not expressing CYP1B1, investigators generated isogenic derivatives expressing the two forms. Proliferation, invasiveness, stem cell characteristics, sensitivity to anticancer agents and transcriptome were analyzed.

Bone Regeneration Capacities of Alveolar Bone Mesenchymal Stem Cells Sheet in Rabbit Calvarial Bone Defect

[Journal of Tissue Engineering] Scientists compared the osteogenic differentiation and bone defect repairment characteristics of bone marrow mesenchymal stem cells sheets derived from alveolar bone and iliac bone in vitro and in vivo.

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