induced pluripotent stem cells

[Journal of Neural Transmission] Whole brain organoids were created from induced pluripotent stem cells from healthy individuals and individuals suffering from autism.

[Nanomedicine] Investigators explored the effect of small extracellular vesicles from induced pluripotent stem cell-derived MSCs on acute pain and investigated the underlying mechanisms.

[Birth Defects Research] To identify embryotoxic compounds, scientists developed an hiPSC-based biomarker assay based on the differentiation of hiPSCs into functional cardiomyocytes and hepatocytes.

[Metabolic Engineering] By screening a fluorescent probe library, investigators found that intracellular glycogen led to specific reactivity to CDg4, a glycogen fluorescence sensor, in both human and mouse naïve ESCs.

[Cell Biochemistry and Function] Researchers employed miPS-Huh7cmP cells to reevaluate the efficacy of diphenyleneiodonium since CSCs are currently one of the main foci of therapeutic strategy to treat cancer, but generally considered resistant to chemotherapy.

[Nature Biotechnology] Investigators generated functionally mature stem-cell-derived islets using an optimized protocol and benchmarked them comprehensively against primary adult islets.