induced pluripotent stem cells

[Cell Biology and Toxicology] Researchers suggested that micro-computed tomography (CT) analyzable pluripotent stem cell (PSC)-derived alveolar human lung organoids were a promising in vitro model to predict lung toxicity manifestations, including fibrosis.

[Cell Stem Cell] The authors reported that iPSCs reprogramed from CD62L+ naive and memory T cells followed by CD19-CAR engineering and 3D-organoid system differentiation conferred products with conventional CD8αβ-positive CAR T cell characteristics.

[Critical Journal of the American Society of Nephrology] Extracellular vesicles derived from reparative cells, such as mesenchymal stem cells, tubular epithelial progenitor cells, and human umbilical cord blood represent promising regenerative tools for treatment of kidney diseases.

[PLoS One] The authors sought to measure respiratory syncytial virus (RSV) replication, cytopathic effects, and protein expression in human lung organoids reproducing architecture and transcriptional profiles of human fetal lungs during the first trimester of gestation.

[Stem Cell Research & Therapy] The authors established a new hiPSCs line derived from amniotic cells of a fetus with a homozygous β41-42 deletion mutation in the HBB gene and a heterozygous Westmead mutation in the HBA2 gene. They designed a CRISPR-Cas9 to target these casual mutations and corrected them.

[Scientific Reports] To rescue the functionally extinct species of the northern white rhinoceros, investigators employed iPSCs to generate gametes and subsequently embryos in vitro.