induced pluripotent stem cells

[Science Advances] Transcriptomic analysis showed that differentiation of hiPSCs derived from diabetics into KDR+CD56+APLNR+ (KNA+) cells was sufficient to change baseline differences in gene expression caused by the diabetic status and reprogram diabetic cells to a pattern similar to KNA+ cells derived from nondiabetic hiPSCs.

[iScience] Scientists developed a method to generate photoreceptor cells (PRCs) from human iPSCs by introducing the transcription factors CRX and NEUROD1, which enabled them to generate induced photoreceptor-like cells (iPRCs) expressing PRC markers.

[Journal of Cellular and Molecular Medicine] The authors transplanted cells that were generated from hiPSCs into regionally specific spinal neural progenitor cells utilizing a novel accelerated differentiation protocol designed for clinical translation.

[Journal of Cellular and Molecular Medicine] Investigators found that the limited expansion of ESC CD34+ cell-derived erythroid cells was associated with defective cell cycle of erythroid progenitors.

[Basic Research in Cardiology] Researchers established an in vitro iPSC model of anthracycline-induced cardiotoxicity (ACT) from patients with an aggressive form of B-cell lymphoma and examined whether doxorubicin-treated ACT-iPSC cardiomyocytes could recapitulate the clinical features exhibited by patients.

[Alchemab Therapeutics] Alchemab Therapeutics, a biotechnology company focused on the discovery and development of naturally-occurring protective antibodies in neurodegeneration and oncology, announced an extension of its collaboration with Medicines Discovery Catapult, a national facility enabling the UK’s community to accelerate innovative drug discovery.