induced pluripotent stem cells

[International Journal of Oral Science] Much extrapolation work is needed to validate that electroactive and electroconductive scaffolds can indeed promote neurogenesis of dental and oral-derived stem cells, which would thus facilitate clinical applications in neuroregeneration therapy.

[Developmental Cell] Scientists revealed that, although all three germ lineages were capable of de novo Gln synthesis, only ectoderm generated sufficient glutamine (Gln) to sustain cell viability and differentiation, and this finding clarified lineage fate restrictions under Gln withdrawal.

[Stem Cell Research & Therapy] The authors found that hemin-treated kidney organoids showed oxidative damage, increased expression of injury markers, impaired functionality of organic anion and cation transport and underwent fibrosis.

[American Journal of Pathology] The authors discuss whether kidney organoids and tubuloids are suitable models for the study of complex human kidney disease and highlights their advantages and limitations compared with monolayer cell culture and animal models.

[Molecular Psychiatry] Investigators used hiPSCs along with CRISPR-Cas9 gene editing to investigate the contribution of chromosome 21 candidate genes to Alzheimer’s disease-relevant neuronal phenotypes.

[Stem Cell Research & Therapy] The authors describe the reconstitution of primordial germ cells and the subsequent meiosis, as well as the signaling pathways and factors involved in these processes.