induced pluripotent stem cells

[Scientific Reports] Researchers developed an artificial intelligence capable of predicting the seizure liability of drugs and identifying drugs using deep learning based on raster plots of neural network activity.

[npj Parkinsons Disease] The authors applied high content imaging on induced pluripotent stem cell-derived neurons from patients with familial Parkinson’s disease bearing the G209A α-synuclein mutation and launched a screening campaign on a small kinase inhibitor library.

[ACS Applied Materials & interfaces] Scientists developed a CRISPR activation iPSC platform that constitutively expressed the dCas9-VPR system, which allowed robust activation of the proneural transcription factor NEUROD1 to rapidly induce neuronal differentiation within seven days.

[Cell Proliferation] Retinal organoids produced from rhesus monkey iPSCs using established protocols differentiated through the stages of organoid development faster than those derived from human stem cells.

[Stem Cell Reviews and Reports] The authors highlight the recent progress on the role of endoplasmic reticulum and mitochondria in maintaining PSCs redox status, focusing on metabolism.

[Journal of Bone and Mineral Research] Scientists provide a comprehensive overview of the different iPSCs to chondrocytes differentiation approaches, the hitherto described iPSC-chondrocyte disease models and mechanistic and/or therapeutic insights that have been derived from their investigation.