Tag results:

induced pluripotent stem cells

Mapping Human Haematopoietic Stem Cells from Haemogenic Endothelium to Birth

[Nature] Scientists created a single-cell transcriptome map of human hematopoietic tissues from the first trimester to birth and found that the hematopoietic stem cell (HSC) signature RUNX1+HOXA9+MLLT3+MECOM+HLF+SPINK2+ distinguished HSCs from progenitors throughout gestation.

Assessment of Safety and Immunogenicity of MHC Homozygous iPSC-Derived CD34+ Hematopoietic Progenitors in a NHP Model

[Blood Advances] The authors demonstrated that infusing hematopoietic progenitors derived from MHC homozygous iPSCs (iHP) were well-tolerated and safe, observing no teratomas or tumors in the Mauritian cynomolgus macaque up to one year after HSC transplant and iHP infusion.

Human Pancreatic Microenvironment Promotes β-Cell Differentiation via Non-canonical WNT5A/JNK and BMP Signaling

[Nature Communications] Researchers uncovered unique factors that guided in vitro development of endocrine progenitors, with WNT5A markedly improving human β-cell differentiation.

β-Cell Mitochondria in Diabetes Mellitus: A Missing Puzzle Piece in the Generation of hPSC-Derived Pancreatic β-Cells?

[Journal of Translational Medicine] Investigators highlight the role of mitochondria in metabolism secretion coupling in the β-cells and summarize the evidence accumulated for the implication of mitochondria in β-cell dysfunction in diabetes mellitus.

Human Pluripotent Stem Cell-Derived Myogenic Progenitors Undergo Maturation to Quiescent Satellite Cells upon Engraftment

[Cell Stem Cell] Using an myogenic progenitor cell (MPC)-specific fluorescent reporter system (PAX7::GFP), scientists demonstrated that hPSC-derived MPCs could contribute to the regeneration of myofibers in mice following local injury and in mice deficient of dystrophin.

Development of iPSC-Based Clinical Trial Selection Platform for Patients with Ultrarare Diseases

[Science Advances] Scientists reported an 18-year-old patient with ultrarare Leigh-like syndrome. They established an iPSC–based platform for this patient, and assessed the efficacy of a panel of drugs.