Retinoic Acid Signaling in Heart Development: Application in the Differentiation of Cardiovascular Lineages from Human Pluripotent Stem Cells

Scientists discuss the role of retinoic acid (RA) in cardiogenesis, currently available protocols that employ RA for differentiation of various cardiovascular lineages, and plausible transcriptional mechanisms underlying this fate specification.
[Stem Cell Reports]
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Integrating Single-Cell Genomics Pipelines to Discover Mechanisms of Stem Cell Differentiation

The authors discuss strategies for scaling stem cell differentiation through multiplexed single-cell analysis, for evaluating molecular regulation of cell differentiation using new analysis algorithms, and methods for integration and projection analysis to classify and benchmark stem cell derivatives against in vivo cell types.
[Trends in Molecular Medicine]
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An Airway Organoid-Based Screen Identifies a Role for the HIF1α-Glycolysis Axis in SARS-CoV-2 Infection

It is urgent to develop disease models to dissect mechanisms regulating SARS-CoV-2 infection. Researchers derived airway organoids from human pluripotent stem cells.
[Cell Reports]
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Modular Self-Assembly System for Development of Oligomeric, Highly Internalizing and Potent Cytotoxic Conjugates Targeting Fibroblast Growth Factor Receptors

Researchers aimed to develop a modular, self-assembly system for generation of oligomeric cytotoxic conjugates, capable of FGFR1 clustering, for targeting FGFR1-overproducing cancer cells.
[Journal of Biomedical Science]
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Cell-Based Therapies for Retinal Diseases: A Review of Clinical Trials and Direct to Consumer “Cell Therapy” Clinics

Scientists outline the particular approaches in the different published clinical trials for cell-based therapies for retinal diseases, and present the controversies surrounding experimental treatments offered outside of legitimate studies.
[Stem Cell Research & Therapy]
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Tracing the Emergence of Primordial Germ Cells from Bilaminar Disc Rabbit Embryos and Pluripotent Stem Cells

Using newly derived rabbit PSCs, investigators showed robust and rapid induction of rabbit primordial germ cell (rbPGC)-like cells in vitro with WNT and BMP morphogens, which revealed SOX17 as the critical regulator of rbPGC fate as in several non-rodent mammals.
[Cell Reports]
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HNF Collaborates with Rarebase on a Drug Discovery Platform to Develop Treatments for Charcot-Marie-Tooth (CMT)

The Hereditary Neuropathy Foundation (HNF), in partnership with Rarebase, is leading the charge in the first-ever research initiative to tackle multiple types of CMT in one project, with a primary goal to test candidate drugs in patient-derived cellular models, specifically; iPSC-derived neurons.
[The Hereditary Neuropathy Foundation]
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Interventional Strategies for Parkinson Disease: Can Neural Precursor Cells Forge a Path Ahead?

The authors discuss the role of PSC-derived neural precursor cells in rat models of MPTP-induced Parkinson’s disease following intranasal injections.
[ACS Chemical Neuroscience]
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Induced Pluripotent Stem Cells for Inherited Optic Neuropathies—Disease Modeling and Therapeutic Development

The authors discuss disease modeling and the therapeutic strategies being explored with iPSC technologies for the 2 most common inherited optic neuropathies, namely, dominant optic atrophy and Leber hereditary optic neuropathy. The rationale and translational advances for cell-based and gene-based therapies are explored, as well as opportunities for neuroprotection and drug screening.
[Journal of Neuro-Ophthalmology]
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Additional Benefit of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cell Therapy on Sepsis Syndrome-Associated Acute Kidney Injury in Rat Treated with Antibiotic

Investigators tested whether human induced-pluripotent stem-cell-derived mesenchymal-stem-cells would offer an additional benefit to the rodent with acute kidney injury associated sepsis syndrome undergoing ciprofloxacin therapy.
[Stem Cell Research & Therapy]
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Century Therapeutics and Outpace Bio Enter Research Collaboration in CAR Engineering

Century Therapeutics and Outpace Bio announced a research collaboration in CAR engineering. The collaboration will bring together Century’s CAR and protein engineering expertise with Outpace’s protein design and synthetic biology capabilities to enhance CAR functionality by combining Outpace’s optimized CAR spacer technology with Century’s VHH domain binders.
[Century Therapeutics (GlobeNewswire, Inc.)]
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