Both human pluripotent stem cell-derived cardiomyocytes and adult cardiomyocytes could be productively infected by SARS-CoV-2, leading to secretion of the monocyte chemoattractant cytokine CCL2 and subsequent monocyte recruitment.
[Stem Cell Reports]
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Human induced pluripotent stem cell derived cardiomyocytes as well as ex vivo and in vivo models of ischemia-reperfusion injury were used to test the efficacy of ASIC1a inhibitors as pre- and post-conditioning therapeutic agents.
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To overcome limitations and address species-specific cellular organization, investigators derived organoids from rapidly developing teleosts.
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The authors identified a potential synergy between mutation in the high-risk autism gene encoding chromodomain helicase DNA binding protein 8 and environmental exposure to an organophosphate pesticide an iPSC-derived human 3D brain model.
[Experimental Health Perspectives]
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Modafferi, S., Zhong, X., Kleensang, A., Murata, Y., Fagiani, F., Pamies, D., Hogberg, H. T., Calabrese, V., Lachman, H., Hartung, T., & Smirnova, L. (n.d.). Gene–Environment Interactions in Developmental Neurotoxicity: a Case Study of Synergy between Chlorpyrifos and CHD8 Knockout in Human BrainSpheres. Environmental Health Perspectives, 129(7), 077001. https://doi.org/10.1289/EHP8580 Cite
The authors present the generation, development, and application of current cellular, animal and potential for bio-printed models, in the study of the pathophysiological mechanisms underlying dystrophin-linked cardiomyopathy in the direction of personalized medicine.
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Scientists investigated the contribution of the X-linked intellectual disability (XLID)-associated RBMX in neuronal differentiation.Transcriptomic analysis of isogenic Shashi-XLID human iPSCs generated using CRISPR-Cas9 revealed a dysregulation of MDM4 splicing and aberrant p53 upregulation.
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Transcription factor-induced reprogramming of somatic cells across lineages and to iPSCs has revealed a remarkable plasticity of differentiated cells and presents great opportunities for generating clinically relevant cell types for disease modeling and regenerative medicine.
[Current Opinion in Genetics & Development]
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Researchers described an optimized protocol to differentiate human iPSCs to a late myogenic stage, allowing them to recapitulate classical Duchenne muscular dystrophy (DMD) phenotypes in isogenic DMD-mutant iPSC lines in vitro.
[Proceedings of the National Academy of Sciences of the United States of America]
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ExCellThera, Inc. announced that it has entered into a licensing agreement with Astellas Pharma, Inc. through its US subsidiary, Astellas Institute for Regenerative Medicine, for the in vitro use of the UM171 compound and certain other molecules in the field of PSCs and PSC-derived cells.
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Hydrogel prepared with alginate and the pancreatic extracellular matrix was assessed for the beneficial outcomes on encapsulated insulin-producing cells.
[ACS Biomaterials Science & Engineering]
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Scientists explored whether human-induced pluripotent stem cells could represent unlimited cell sources for neo-cartilage comparable to human primary articular chondrocytes or human bone marrow-derived MSCs.
[Cell and Tissue Research]
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