Investigators established a hiPSC-derived neuron model for the investigation of axonal lysosome transport and maturation and showed that loss of JIP3 resulted in the accumulation of axonal lysosomes and the Alzheimer’s disease-related amyloid precursor protein-derived Aβ42 peptide.
[Molecular Biology of the Cell]
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Gowrishankar, S., Lyons, L., Rafiq, N. M., Roczniak-Ferguson, A., De Camilli, P., & Ferguson, S. M. (2021). Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons. Molecular Biology of the Cell, mbc.E20-06-0382. https://doi.org/10.1091/mbc.E20-06-0382 Cite
To elucidate the underlying pathogenic mechanisms of myoclonus dystonia, scientists investigated iPSC-derived striatal medium spiny neurons from two myoclonus-dystonia patients carrying a heterozygous mutation in the SGCE gene in comparison to two matched healthy control lines.
[International Journal of Molecular Sciences]
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Kutschenko, A., Staege, S., Grütz, K., Glaß, H., Kalmbach, N., Gschwendtberger, T., Henkel, L. M., Heine, J., Grünewald, A., Hermann, A., Seibler, P., & Wegner, F. (2021). Functional and Molecular Properties of DYT-SGCE Myoclonus-Dystonia Patient-Derived Striatal Medium Spiny Neurons. International Journal of Molecular Sciences, 22(7), 3565. https://doi.org/10.3390/ijms22073565 Cite
The authors reviewed the molecular basis of reprogramming, including the reprogramming factors, applied vectors and epigenetic modifications to provide a comprehensive guide for reprogramming studies.
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Researchers identified two markers for myogenic cell purification: CDH13, which purified most of the myogenic cells, and FGFR4, which purified a subset of muscle progenitor cells.
[Stem Cell Reports]
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Nalbandian, M., Zhao, M., Sasaki-Honda, M., Jonouchi, T., Lucena-Cacace, A., Mizusawa, T., Yasuda, M., Yoshida, Y., Hotta, A., & Sakurai, H. (2021). Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.03.004 Cite
Investigators demonstrated successful encapsulation, spheroid formation and high viability for three different hPSC lines. Using one of the hPSC lines they demonstrated maintenance of pluripotency and successful differentiation of stem cell spheroids into β-cells.
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Transplantation of the hiPSC-derived neural crest cells rapidly restored rabbit corneal thickness and clarity. However, the long-term recovery efficacy was impaired by the improper maturation, senescence, and endothelial-mesenchymal transition of the transplanted cells.
[Stem Cell Research & Therapy]
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The authors found that nuclear factor erythroid 2 p45-related factor 2 (NRF2) played an important role in the maturation of hiPSC-derived cardiomyocytes.
[Stem Cell Research & Therapy]
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FUJIFILM Cellular Dynamics, Inc. and Sana Biotechnology, Inc. announced that Sana has been granted a non-exclusive right to use FUJIFILM Cellular Dynamics’ iPSC platform for the development of commercial cell therapies.
[FUJIFILM Cellular Dynamics, Inc.]
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Scientists investigated the role that overexpression of UPF1, a protein involved in nonsense-mediated decay, plays in mitigating neurotoxicity in multiple models of C9orf72 ALS/FTD.
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In cell lines derived from Parkinson’s disease patients, astrocytes were characterized by a significant decrease in S100B and GFAP-positive astrocytic profiles associated with marked decrease in astrocyte complexity.
[npj Parkinsons Disease]
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Sequential waves of definitive hematopoiesis arise from yolk sac and intembryonic hemogenic endothelia through an endothelial-to-hematopoietic transition.