Overlapping Roles of JIP3 and JIP4 in Promoting Axonal Transport of Lysosomes in Human iPSC-Derived Neurons

Investigators established a hiPSC-derived neuron model for the investigation of axonal lysosome transport and maturation and showed that loss of JIP3 resulted in the accumulation of axonal lysosomes and the Alzheimer’s disease-related amyloid precursor protein-derived Aβ42 peptide.
[Molecular Biology of the Cell]
Gowrishankar, S., Lyons, L., Rafiq, N. M., Roczniak-Ferguson, A., De Camilli, P., & Ferguson, S. M. (2021). Overlapping roles of JIP3 and JIP4 in promoting axonal transport of lysosomes in human iPSC-derived neurons. Molecular Biology of the Cell, mbc.E20-06-0382. https://doi.org/10.1091/mbc.E20-06-0382 Cite
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Functional and Molecular Properties of DYT-SGCE Myoclonus-Dystonia Patient-Derived Striatal Medium Spiny Neurons

To elucidate the underlying pathogenic mechanisms of myoclonus dystonia, scientists investigated iPSC-derived striatal medium spiny neurons from two myoclonus-dystonia patients carrying a heterozygous mutation in the SGCE gene in comparison to two matched healthy control lines.
[International Journal of Molecular Sciences]
Kutschenko, A., Staege, S., Grütz, K., Glaß, H., Kalmbach, N., Gschwendtberger, T., Henkel, L. M., Heine, J., Grünewald, A., Hermann, A., Seibler, P., & Wegner, F. (2021). Functional and Molecular Properties of DYT-SGCE Myoclonus-Dystonia Patient-Derived Striatal Medium Spiny Neurons. International Journal of Molecular Sciences, 22(7), 3565. https://doi.org/10.3390/ijms22073565 Cite
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Induced Pluripotent Stem Cell Technology: Trends in Molecular Biology, from Genetics to Epigenetics

The authors reviewed the molecular basis of reprogramming, including the reprogramming factors, applied vectors and epigenetic modifications to provide a comprehensive guide for reprogramming studies.
[Epigenomics]
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Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy

Researchers identified two markers for myogenic cell purification: CDH13, which purified most of the myogenic cells, and FGFR4, which purified a subset of muscle progenitor cells.
[Stem Cell Reports]
Nalbandian, M., Zhao, M., Sasaki-Honda, M., Jonouchi, T., Lucena-Cacace, A., Mizusawa, T., Yasuda, M., Yoshida, Y., Hotta, A., & Sakurai, H. (2021). Characterization of hiPSC-Derived Muscle Progenitors Reveals Distinctive Markers for Myogenic Cell Purification Toward Cell Therapy. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.03.004 Cite
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Core–Shell Hydrogel Microcapsules Enable Formation of Human Pluripotent Stem Cell Spheroids and Their Cultivation in a Stirred Bioreactor

Investigators demonstrated successful encapsulation, spheroid formation and high viability for three different hPSC lines. Using one of the hPSC lines they demonstrated maintenance of pluripotency and successful differentiation of stem cell spheroids into β-cells.
[Scientific Reports]
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Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Crest Cells for Corneal Endothelial Regeneration

Transplantation of the hiPSC-derived neural crest cells rapidly restored rabbit corneal thickness and clarity. However, the long-term recovery efficacy was impaired by the improper maturation, senescence, and endothelial-mesenchymal transition of the transplanted cells.
[Stem Cell Research & Therapy]
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NRF2 Is Required for Structural and Metabolic Maturation of Human Induced Pluripotent Stem Cell-Derived Ardiomyocytes

The authors found that nuclear factor erythroid 2 p45-related factor 2 (NRF2) played an important role in the maturation of hiPSC-derived cardiomyocytes.
[Stem Cell Research & Therapy]
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FUJIFILM Cellular Dynamics and Sana Biotechnology Announce License Agreement for the Development of iPSC-Derived Cell Therapies

FUJIFILM Cellular Dynamics, Inc. and Sana Biotechnology, Inc. announced that Sana has been granted a non-exclusive right to use FUJIFILM Cellular Dynamics’ iPSC platform for the development of commercial cell therapies.
[FUJIFILM Cellular Dynamics, Inc.]
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UPF1 Reduces C9orf72 HRE-Induced Neurotoxicity in the Absence of Nonsense-Mediated Decay Dysfunction

Scientists investigated the role that overexpression of UPF1, a protein involved in nonsense-mediated decay, plays in mitigating neurotoxicity in multiple models of C9orf72 ALS/FTD.
[Cell Reports]
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Astrocytic Atrophy as a Pathological Feature of Parkinson’s Disease with LRRK2 Mutation

In cell lines derived from Parkinson’s disease patients, astrocytes were characterized by a significant decrease in S100B and GFAP-positive astrocytic profiles associated with marked decrease in astrocyte complexity.
[npj Parkinsons Disease]
Ramos-Gonzalez, P., Mato, S., Chara, J. C., Verkhratsky, A., Matute, C., & Cavaliere, F. (2021). Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutation. Npj Parkinson’s Disease, 7(1), 1–11. https://doi.org/10.1038/s41531-021-00175-w Cite
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First Blood: The Endothelial Origins of Hematopoietic Progenitors

Sequential waves of definitive hematopoiesis arise from yolk sac and intembryonic hemogenic endothelia through an endothelial-to-hematopoietic transition.
[Angiogenesis]
Canu, G., & Ruhrberg, C. (2021). First blood: the endothelial origins of hematopoietic progenitors. Angiogenesis. https://doi.org/10.1007/s10456-021-09783-9 Cite
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