Tag results:

induced pluripotent stem cells

Retroviral Infection of Human Neurospheres and Use of Stem Cell EVs to Repair Cellular Damage

[Scientific Reports] Investigators reported the generation of neurospheres from iPSC-derived neural progenitor cells and showed that these cultures were permissive to retroviral replication.

Modeling Axonal Regeneration by Changing Cytoskeletal Dynamics in Stem Cell-Derived Motor Nerve Organoids

[Scientific Reports] Researchers established motor nerve organoids from human PSCs with properties similar to those of neuromesodermal progenitors, a population of progenitor cells that comprise the caudal spinal cord.

In Situ Monitoring Reveals Cellular Environmental Instabilities in Human Pluripotent Stem Cell Culture

[Communications Biology] Scientists performed frequent in situ monitoring of dissolved O2 and CO2 with optical sensor spots and contemporaneous evaluation of cell proliferation and medium pH in standard batch cultures of three widely used human somatic and PSC lines.

Role of mTORC1 Activity during Early Retinal Development and Lamination in Human-Induced Pluripotent Stem Cell-Derived Retinal Organoids

[Cell Death Discovery] Using hiPSC-derived retinal organoids, researchers identified the time-dependent role of mammalian target of rapamycin complex 1 (mTORC1) in retinal development, specifically in retinal ganglion cell differentiation and the retinal lamination process, during the early stages of retinal organoid development.

Human Pluripotent Stem-Cell-Derived Islets Ameliorate Diabetes in Non-Human Primates

[Nature Medicine] Researchers generated islets from human chemically induced PSCs (hCiPSC-islets) and showed that a one-dose intraportal infusion of hCiPSC-islets into diabetic non-human primates effectively restored endogenous insulin secretion and improved glycemic control.

CDH18 Is a Fetal Epicardial Biomarker Regulating Differentiation towards Vascular Smooth Muscle Cells

[NPJ Regenerative Medicine] Scientists recapitulated epicardiogenesis using human iiPSCs and identified type II classical cadherin CDH18 as a biomarker defining lineage specification in human active epicardium.

Popular