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induced pluripotent stem cells

Leveraging Interacting Signaling Pathways to Robustly Improve the Quality and Yield of Human Pluripotent Stem Cell-Derived Hepatoblasts and Hepatocytes

[Stem Cell Reports] By leveraging recent knowledge of the signaling pathways involved in liver development, investigators described a robust, scalable protocol that allowed them to consistently generate high-quality bipotent human hepatoblasts and hepatocyte-like cells from both ESCs and iPSCs.

iPSC-Based Disease Modeling and Drug Discovery in Cardinal Neurodegenerative Disorders

[Cell Stem Cell] The authors outline advances in iPSC modeling and therapeutic development for cardinal neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson’s disease, and Alzheimer’s disease.

BACE2 Variant Identified from HSCR Patient Causes AD-Like Phenotypes in hPSC-Derived Brain Organoids

[Cell Death Discovery] Using the human pluripotent stem cell (hPSC)-derived brain organoids (BOs), investigators demonstrated that β-site APP-cleaving enzyme 2 (BACE2) was mainly expressed in the ventricular zone and cortical plate of BOs, and its expression level was gradually increased along with the BO maturation.

Sustainable Antiviral Efficacy of Rejuvenated HIV-Specific Cytotoxic T Lymphocytes Generated from Induced Pluripotent Stem Cells

[Journal of Virology] Scientists assessed the antiviral efficacy of HIV-specific iPSC-cytotoxic T lymphocytes by single- and multiple-round viral suppression assays.

Human iPSC-Derived Neural Models for Studying Alzheimer’s Disease: From Neural Stem Cells to Cerebral Organoids

[Stem Cell Reviews and Reports] The authors summarize currently used differentiation strategies of iPSCs towards neuronal and glial cell types and cerebral organoids and their utilization in modeling Alzheimer’s disease and potential drug discovery.

Generation of the Organotypic Kidney Structure by Integrating Pluripotent Stem Cell-Derived Renal Stroma

[Nature Communications] By elucidating the in vivo molecular features of the renal stromal lineage at a single-cell resolution level, researchers herein established an in vitro induction protocol for stromal progenitors from mouse PSCs.

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