induced pluripotent stem cells

[iScience] Using iPSC derived-kidney organoids, SARS-CoV-1, SARS-CoV-2 and MERS-CoV tropism, defined by the paired expression of a host receptor and protease, was identified primarily amongst proximal tubule cells.

[Ebiomedicine] Scientists discuss the advantages and limitations of 2D human pluripotent stem cell (hPSC)-cardiomyocyte system, and introduce the recent development of three-dimensional culture platforms derived from hPSCs.

[eLife] Researchers investigated the dynamics of basement membrane assembly in human pluripotent stem cell-derived kidney organoids.

[iScience] Researchers found that the metabolites most enriched during the differentiation from pluripotent stem cell to lung progenitor cell, regardless of cell line, were sphingomyelins and phosphatidylcholines, two important lipid classes in lung development.

[Molecular Reproduction and Development] Scientists introduce the research advance of both somatic cell reprogramming and early embryonic development, indicating that the mechanisms of iPSCs also shares common features with that of early embryonic development in several aspects.

[Gene Therapy] The authors indicated that the IONIS 486178 antisense oligonucleotide (ASO) targeted mutant DMPK mRNAs in the brain and strongly supported the feasibility of a therapy for dystrophia myotonica type 1 patients based on the intrathecal injection of an ASO.