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induced pluripotent stem cells

Single-Cell Sequencing Reveals Lineage-Specific Dynamic Genetic Regulation of Gene Expression during Human Cardiomyocyte Differentiation

[PLoS Genetics] During a dynamic process such as cellular differentiation, the overall cell type composition of a tissue (or an in vitro culture) and the gene regulatory profile of each cell can both experience significant changes over time.

Correction of a Factor VIII Genomic Inversion with Designer-Recombinases

[Nature Communications] Transient recombinase system treatment of endothelial cells, differentiated from patient-derived induced pluripotent stem cells of a hemophilic donor, resulted in 12% correction of the inversion and restored Factor VIII mRNA expression.

Histone Variant macroH2A1.1 Enhances Non-homologous End Joining-Dependent DNA Double-Strand-Break Repair and Reprogramming Efficiency of Human iPSCs

[Stem Cells] Researchers evaluated the splicing isoforms of histone variant macroH2A1, macroH2A1.1 and macroH2A1.2, as potential regulators of DNA damage repair during iPSC reprogramming.

Selective Elimination of Pluripotent Stem Cells by PIKfyve Specific Inhibitors

[Stem Cell Reports] Scientists showed that PIKfyve inhibitors could selectively eliminate pluripotent embryonal carcinoma cells, ESCs, and iPSCs under conditions where differentiated cells remained viable.

Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells

[Diabetes] Researchers studied maturity-onset diabetes of the young 1 using human iPSC-derived pancreatic β-like patient and isogenic control cell lines in two different 3D contexts.

Integrated Fibroblast Growth Factor Signal Disruptions in Human iPS Cells for Prediction of Teratogenic Toxicity of Chemicals

[Journal of Bioscience and Bioengineering] Investigators developed a reporter assay using human iPSCs to detect changes in the fibroblast growth factor signaling pathway, a pathway essential for limb morphogenesis.

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