Tag results:
induced pluripotent stem cells
Muscle Cell News
Single-Cell Sequencing Reveals Lineage-Specific Dynamic Genetic Regulation of Gene Expression during Human Cardiomyocyte Differentiation
[PLoS Genetics] During a dynamic process such as cellular differentiation, the overall cell type composition of a tissue (or an in vitro culture) and the gene regulatory profile of each cell can both experience significant changes over time.
Endothelial Cell News
Correction of a Factor VIII Genomic Inversion with Designer-Recombinases
[Nature Communications] Transient recombinase system treatment of endothelial cells, differentiated from patient-derived induced pluripotent stem cells of a hemophilic donor, resulted in 12% correction of the inversion and restored Factor VIII mRNA expression.
ESC & iPSC News
Histone Variant macroH2A1.1 Enhances Non-homologous End Joining-Dependent DNA Double-Strand-Break Repair and Reprogramming Efficiency of Human iPSCs
[Stem Cells] Researchers evaluated the splicing isoforms of histone variant macroH2A1, macroH2A1.1 and macroH2A1.2, as potential regulators of DNA damage repair during iPSC reprogramming.
ESC & iPSC News
Selective Elimination of Pluripotent Stem Cells by PIKfyve Specific Inhibitors
[Stem Cell Reports] Scientists showed that PIKfyve inhibitors could selectively eliminate pluripotent embryonal carcinoma cells, ESCs, and iPSCs under conditions where differentiated cells remained viable.
ESC & iPSC News
Spatial Environment Affects HNF4A Mutation-Specific Proteome Signatures and Cellular Morphology in hiPSC-Derived β-Like Cells
[Diabetes] Researchers studied maturity-onset diabetes of the young 1 using human iPSC-derived pancreatic β-like patient and isogenic control cell lines in two different 3D contexts.
ESC & iPSC News
Integrated Fibroblast Growth Factor Signal Disruptions in Human iPS Cells for Prediction of Teratogenic Toxicity of Chemicals
[Journal of Bioscience and Bioengineering] Investigators developed a reporter assay using human iPSCs to detect changes in the fibroblast growth factor signaling pathway, a pathway essential for limb morphogenesis.