induced pluripotent stem cells

[Stem Cell Research & Therapy] Scientists assessed the role of thymosin β-4 on endothelial function using diabetic human induced pluripotent stem cells derived endothelial cells as disease model of endothelial dysfunction.

[iScience] Scientists proposed a reporter assay that utilized human iPSCs to detect changes in fibroblast growth factor signaling, which was essential for limb morphogenesis.

[eLife] The authors reported a novel stepwise strategy for directing the simultaneous induction of both mesoderm-derived cardiac and endoderm-derived lung epithelial lineages within a single differentiation of human iPSCs via temporal specific tuning of WNT and nodal signaling in the absence of exogenous growth factors.

[Communications Biology] Researchers investigated Parkinson’s disease (PD)'s mechanism using dopaminergic neurons differentiated from human iPSCs carrying the ILE368ASN mutation within the PINK1 gene, which is strongly associated with PD.

[Stem Cell Reports] Investigators studied human iPSCs that had been expanded into a self-formed ectodermal autonomous multi-zone of cells that partially mimicked human eye development.

[Cell Tissues Organs] Investigators developed a new method to generate 3D spatial-organized cardiac organoids from 2D micropatterned hiPSC colonies, instead of directly from 3D stem cell aggregates.