Scientists advocate for a paradigm shift towards the application of human iPSC-derived systems for Alzheimer’s and Parkinson’s disease modeling and the development of improved human-based models in a dish for drug discovery and preclinical assessment of therapeutic targets.
[Molecular Therapy]
MacDougall, G., Brown, L. Y., Kantor, B., & Chiba-Falek, O. (2021). The path to progress preclinical studies of age-related neurodegenerative diseases: A perspective on rodent and hiPSC-derived models. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.01.001 Cite
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