Hair Follicle Stem Cells for Tissue Regeneration

The authors discuss the various stem cell types identified in rodent and human hair follicles and ongoing studies on the potential use of hair follicle stem cells for skin, bone, cardio-vascular, and nerve tissue engineering.
[Tissue Engineering Part B-Reviews]
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Hypoimmune Induced Pluripotent Stem Cell–Derived Cell Therapeutics Treat Cardiovascular and Pulmonary Diseases in Immunocompetent Allogeneic Mice

Investigators showed that gene-edited, immune-evasive cell grafts could survive and successfully treat diseases in immunocompetent, fully allogeneic recipients. A mixture of endothelial cells and cardiomyocytes was injected into infarcted mouse hearts, and both cell types orthotopically engrafted in the ischemic areas.
[Proceedings of the National Academy of Sciences of the United States of America]
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Adenine Base Editing Reduces Misfolded Protein Accumulation and Toxicity in Alpha-1 Antitrypsin Deficient Patient iPSC-Hepatocytes

Researchers applied adenine base editors to correct the Z mutation in patient-induced pluripotent stem cells (iPSCs) and iPSC-derived hepatocytes.
[Molecular Therapy]
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Intestinal Multicellular Organoids to Study Colorectal Cancer

Modeling colorectal cancer (CRC) using organoids has burgeoned in the last decade, providing enhanced in vitro models to study the development and possible treatment options for this type of cancer. The authors describe both normal and CRC intestinal organoid models and their utility in the cancer research field.
[Biochimica et Biophysica Acta-Reviews On Cancer]
Idris, M., Alves, M. M., Hofstra, R. M. W., Mahe, M. M., & Melotte, V. (2021). Intestinal multicellular organoids to study colorectal cancer. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1876(2), 188586. https://doi.org/10.1016/j.bbcan.2021.188586 Cite
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Single-Cell-Resolved Differentiation of Human Induced Pluripotent Stem Cells into Pancreatic Duct-Like Organoids on a Microwell Chip

Researchers reported the single-cell characterization of the differentiation of pancreatic duct-like organoids from human induced pluripotent stem cells (hiPSCs) on a microwell chip that facilitated the uniform aggregation and chemical induction of hiPSC-derived pancreatic progenitors.
[Nature Biomedical Engineering]
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Multicellular Modeling of Ciliopathy by Combining iPS Cells and Microfluidic Airway-on-a-Chip Technology

Researchers combined human iPSCs and airway-on-a-chip technology to demonstrate the effectiveness of fluid shear stress for regulating the global axis of multicellular planar cell polarity, as well as inducing ciliogenesis, thereby contributing to quantifiable unidirectional mucociliary flow.
[Science Translational Medicine]
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Generation of Caudal-Type Serotonin Neurons and Hindbrain-Fate Organoids from hPSCs

Scientists proposed a novel strategy to generate hindbrain serotonin (5-HT) neurons from human PSCs, which involved the formation of ventral-type neural progenitor cells and stimulation of the hindbrain 5-HT neural development.
[Stem Cell Reports]
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Dysregulated ECM Remodeling Proteins Lead to Aberrant Osteogenesis of Costello Syndrome iPSCs

Scientists used Costello syndrome induced pluripotent stem cells (iPSCs) undergoing osteogenic differentiation to investigate how dysregulation of extracellular matrix (ECM) remodeling proteins contributed to impaired osteogenesis.
[Stem Cell Reports]
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The Plant Hormone Abscisic Acid Stimulates Megakaryocyte Differentiation from Human iPSCs In Vitro

Investigators found that the plant hormone abscisic acid could increase the generation of megakaryocytes and platelets from human iPSCs.
[Platelets]
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JMJD3: A Critical Epigenetic Regulator in Stem Cell Fate

JMJD3 has been found to enhance self-renewal ability and reduce the differentiation capacity of ESCs and multipotent stem cells. The authors discuss the recent advances of JMJD3 function in stem cell fate.
[Cell Communication and Signaling]
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$6.3 Million for Ground-Breaking Stem Cell Research Projects

Researchers from the University of Sydney have been awarded $6.3 million for three projects which will address stem cell derived-retinal organoids for blindness in adults, iPSC derived cardiomyocytes for chronic heart failure, and help to improve decisions about access to stem cell interventions.
[The University of Sydney]
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