The authors report a method to generate ureteric bud organoids that possess epithelial polarity and tubular lumen and repeat branching morphogenesis.
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The authors investigated the therapeutic potential of neural precursor cells derived from human HLA‐homozygous induced pluripotent stem cells following intracerebral transplantation into a rodent model of middle cerebral artery occlusion.
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Researchers used targeted gene editing to introduce the inducible Caspase-9 system into human iPSCs, and then interrogated the efficiency of inducible apoptosis with normal iPSCs as well as diseased iPSCs derived from patients with acute myeloid leukemia.
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Scientists identified the reference genes best suited for experiments that induce osteogenic differentiation from human induced pluripotent stem cells.
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The authors demonstrated interfacing of cardiomyocytes derived from human induced pluripotent stem cells, which were engineered to express Channelrhodopsin-2.
[npj Flexible Electronics]
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By taking advantage of a human induced pluripotent stem cell-based model, scientists aimed to gain insights on the impact of amyotrophic lateral sclerosis (ALS) mutant FUS on the motoneuron proteome.
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Researchers investigated whether combined modulation of BMP, FGF, and RA signaling pathways could enrich the differentiation of sinoatrial node-like cells from human pluripotent stem cells.
[Stem Cell Research & Therapy]
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How rapamycin affects cardiomyocyte differentiation of induced pluripotent stem cells is still not fully understood. The authors investigated the effect of rapamycin on cardiomyocyte differentiation based on the embryoid body method.
[Stem Cells and Development]
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Scientists analyzed whether defects in DNA replication contributed to genomic instability and the diverse differentiation potentials of reprogrammed pluripotent stem cells.
[Journal of Cell Biology]
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Notch Therapeutics Inc. announced the appointment of David Main as President and Chief Executive Officer.
[Notch Therapeutics Inc.]
Researchers investigated the efficacy and mechanism of the Bio 3D conduit composed of xeno-free human induced pluripotent stem cell–derived mesenchymal stem cells.
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Mitsuzawa, S., Zhao, C., Ikeguchi, R., Aoyama, T., Kamiya, D., Ando, M., Takeuchi, H., Akieda, S., Nakayama, K., Matsuda, S., & Ikeya, M. (2020). Pro-angiogenic scaffold-free Bio three-dimensional conduit developed from human induced pluripotent stem cell-derived mesenchymal stem cells promotes peripheral nerve regeneration. Scientific Reports, 10(1), 12034. https://doi.org/10.1038/s41598-020-68745-1 Cite
The authors report ARID1A, a DNA-binding subunit of the SWI/SNF epigenetic complex, controls both neurogenesis and cardiogenesis from human embryonic stem cells through distinct mechanisms.
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