Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential

The authors report a method to generate ureteric bud organoids that possess epithelial polarity and tubular lumen and repeat branching morphogenesis.
[Cell Reports]
Mae, S.-I., Ryosaka, M., Sakamoto, S., Matsuse, K., Nozaki, A., Igami, M., Kabai, R., Watanabe, A., & Osafune, K. (2020). Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential. Cell Reports, 32(4). https://doi.org/10.1016/j.celrep.2020.107963 Cite
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Intracerebral Transplantation of HLA‐Homozygous Human iPSC‐Derived Neural Precursors Ameliorates the Behavioral and Pathological Deficits in a Rodent Model of Ischemic Stroke

The authors investigated the therapeutic potential of neural precursor cells derived from human HLA‐homozygous induced pluripotent stem cells following intracerebral transplantation into a rodent model of middle cerebral artery occlusion.
[Cell Proliferation]
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Sufficiency for Inducible Caspase-9 Safety Switch in Human Pluripotent Stem Cells and Disease Cells

Researchers used targeted gene editing to introduce the inducible Caspase-9 system into human iPSCs, and then interrogated the efficiency of inducible apoptosis with normal iPSCs as well as diseased iPSCs derived from patients with acute myeloid leukemia.
[Gene Therapy]
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RT-qPCR Analyses on the Osteogenic Differentiation from Human iPS Cells: An Investigation of Reference Genes

Scientists identified the reference genes best suited for experiments that induce osteogenic differentiation from human induced pluripotent stem cells.
[Scientific Reports]
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Printed Elastic Membranes for Multimodal Pacing and Recording of Human Stem-Cell-Derived Cardiomyocytes

The authors demonstrated interfacing of cardiomyocytes derived from human induced pluripotent stem cells, which were engineered to express Channelrhodopsin-2.
[npj Flexible Electronics]
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Proteomics Analysis of FUS Mutant Human Motoneurons Reveals Altered Regulation of Cytoskeleton and Other ALS-Linked Proteins via 3′UTR Binding

By taking advantage of a human induced pluripotent stem cell-based model, scientists aimed to gain insights on the impact of amyotrophic lateral sclerosis (ALS) mutant FUS on the motoneuron proteome.
[Scientific Reports]
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Enrichment Differentiation of Human Induced Pluripotent Stem Cells into Sinoatrial Node-Like Cells by Combined Modulation of BMP, FGF, and RA Signaling Pathways

Researchers investigated whether combined modulation of BMP, FGF, and RA signaling pathways could enrich the differentiation of sinoatrial node-like cells from human pluripotent stem cells.
[Stem Cell Research & Therapy]
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Rapamycin Promotes Cardiomyocyte Differentiation of Human Induced Pluripotent Stem Cells in a Stage-Dependent Manner

How rapamycin affects cardiomyocyte differentiation of induced pluripotent stem cells is still not fully understood. The authors investigated the effect of rapamycin on cardiomyocyte differentiation based on the embryoid body method.
[Stem Cells and Development]
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Pluripotent Stem Cells with Low Differentiation Potential Contain Incompletely Reprogrammed DNA Replication

Scientists analyzed whether defects in DNA replication contributed to genomic instability and the diverse differentiation potentials of reprogrammed pluripotent stem cells.
[Journal of Cell Biology]
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Notch Therapeutics Appoints David Main as President and Chief Executive Officer to Advance the Company’s Novel Gene-Edited, iPSC-Derived Immune Cell Therapeutics

Notch Therapeutics Inc. announced the appointment of David Main as President and Chief Executive Officer.
[Notch Therapeutics Inc.]
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Pro-Angiogenic Scaffold-Free Bio Three-Dimensional Conduit Developed from Human Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells Promotes Peripheral Nerve Regeneration

Researchers investigated the efficacy and mechanism of the Bio 3D conduit composed of xeno-free human induced pluripotent stem cell–derived mesenchymal stem cells.
[Scientific Reports]
Mitsuzawa, S., Zhao, C., Ikeguchi, R., Aoyama, T., Kamiya, D., Ando, M., Takeuchi, H., Akieda, S., Nakayama, K., Matsuda, S., & Ikeya, M. (2020). Pro-angiogenic scaffold-free Bio three-dimensional conduit developed from human induced pluripotent stem cell-derived mesenchymal stem cells promotes peripheral nerve regeneration. Scientific Reports, 10(1), 12034. https://doi.org/10.1038/s41598-020-68745-1 Cite
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Genome-Wide Studies Reveal the Essential and Opposite Roles of ARID1A in Controlling Human Cardiogenesis and Neurogenesis from Pluripotent Stem Cells

The authors report ARID1A, a DNA-binding subunit of the SWI/SNF epigenetic complex, controls both neurogenesis and cardiogenesis from human embryonic stem cells through distinct mechanisms.
[Genome Biology]
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