induced pluripotent stem cells

[Stem Cell Reports] Scientists developed a “disease in a dish” model for Oculocutaneous albinism (OCA) 1A and OCA2 types using iPSCs to generate retinal pigment epithelium.

[Stem Cell Reports] The authors found that, despite the enrichment of histone 3 lysine 79 methylation on thousands of actively transcribed genes in somatic cells, disruptor of telomeric silencing 1-like (DOT1L) inhibition did not immediately cause the shutdown of the somatic transcriptional profile to enable transition to pluripotency.

[iScience] Researchers directly compared the mutation burden of cultured iPSCs with their isogenic embryonic cells during human embryogenesis.

[Nature Protocols] Scientists presented how to generate 3D spheroids resembling specific domains of the nervous system and then how to integrate them physically to allow axonal projections and synaptic assembly.

[Frontiers in Molecular Neuroscience] Investigators gather what is known about the impact of phenylalanine in the brain of patients and highlight where hiPSC-derived organoids could contribute to the understanding of this disease.

[Scientific Reports] Investigators established a model of CSCs that was originally developed from mouse induced pluripotent stem cells (miPSCs) by proposing miPSCs to the conditioned medium of cancer derived cells, which was a mimic of carcinoma microenvironment.