induced pluripotent stem cells

[Journal of Cancer] Scientists performed a series of experiments to verify whether HIF1α, HIF2α and Sox2 regulated glioma cell dedifferentiation under hypoxic conditions. Sphere formation by single glioma cells was observed, and CD133 and CD15 expression was compared between the normoxic and hypoxic groups.

[Advanced Science] A proteome map of COVID-19 skin was established and the susceptibility of human-induced pluripotent stem cell-derived skin organoids with hair follicles and nervous system was investigated, to SARS-CoV-2 infection.

[Journal of Clinical Investigation] The authors developed a therapeutic regimen consisting of the combination of human PSC-derived corneal endothelial precursors with nicotinamide for effective treatment of corneal endothelial dysfunction.

[Stem Cells International] Scientists discovered that p57Kip2 (p57), a cyclin-dependent kinase inhibitor canonically inhibiting cell proliferation, played a role in suppressing the pluripotency state of mouse ESCs.

[Proceedings of the National Academy of Sciences of the United States of America] To facilitate further genetic study of human-chimpanzee divergence, investigators generated human and chimpanzee autotetraploids and allotetraploids by fusing iPSCs of each species.

[Stem Cell Reports] Directed neuronal differentiation of human PSCs, neural progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly reproducible differentiation of mature and functional neurons.