induced pluripotent stem cells

[BlueCube Bio (BioSpace, Inc.)] BlueCube Bio officially announced a company name transition to Evia Bio™, concurrent with the launch of a significant new cryopreservation technology for use in cell and gene therapies utilizing iPSCs.

[Scientific Reports] Researchers investigated the potential of CSC differentiation into blood cells under chemical hypoxic conditions using CoCl2. CSCs and miPS-LLCcm cells were cultured for one to seven days in the presence of CoCl2, and the expression of VEGFR1/2, Runx1, c-kit, CD31, CD34, and TER-119 was assessed by RT-qPCR, Western blotting and flow cytometry together with Wright-Giemsa staining and immunocytochemistry.

[Cellular & Molecular Immunology] Researchers unveiled the guiding role of three essential factors, Lhx2, Hoxa9, and Runx1, the simultaneous expression of which preferentially drove B lineage fate commitment and in vivo B lymphopoiesis using PSCs as a cell source.

[Communications Biology] In iPSC-derived retinal pigment epithelium from late-onset retinal degeneration patients, researchers showed that the dominant pathogenic CTRP5 variant led to reduced CTRP5 secretion.

[Stem Cell Reports] Investigators established a robotic platform and automated all essential steps of human iPSC culture and differentiation under chemically defined conditions.

[Stem Cell Research] The authors generated an iPSC line from the skin fibroblasts collected from a healthy 50-year old male donor. This model that could be used to model physiological processes and screen drug validation in vitro.