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induced pluripotent stem cells

Pluripotent Stem Cells Related to Embryonic Disc Exhibit Common Self-Renewal Requirements in Diverse Livestock Species

[Development] The authors showed that the combination of activin A, fibroblast growth factor and the Wnt inhibitor XAV939 supported establishment and continuous expansion of PSC lines from porcine, ovine and bovine embryos.

The iPSC Perspective on Schizophrenia

[Trends in Neurosciences] The authors highlight reproducible findings and emerging trends in recent schizophrenia-related iPSC studies and illuminate the relevance of the results in the context of human brain development.

STEM CELLS Translational Medicine’s Latest Young Investigator Award Winner Aims to Stop the Devastation Caused by Stroke

[Stem Cells Translational Medicine] Dr. Sara Palma-Tortosa is the 2021 recipient of the STEM CELLS Translational Medicine (SCTM) Young Investigator Award. The award honors a young researcher who served as the principal author of an article published in SCTM that, over the course of a year, is deemed to have the most impact.

Congenital Deficiency Reveals Critical Role of ISG15 in Skin Homeostasis

[Journal of Clinical Investigation] Investigators described two siblings with recurrent skin ulcers that healed with scar formation upon corticosteroid treatment and characterized ISG15-/- dermal fibroblasts, HaCaT keratinocytes, and human induced pluripotent stem cell-derived vascular endothelial cells.

Genome-Wide Differential Expression Profiling of lncRNAs and mRNAs in Human Induced Pluripotent Stem Cell-Derived Endothelial Cells Exposed to E-Cigarette Extract

[Stem Cell Research & Therapy] Researchers identified lncRNAs that were dysregulated in human induced pluripotent stem cell-derived endothelial cells following 24 hours of electronic-cigarette aerosol extract treatment via microarray analysis.

Functional Human Gastrointestinal Organoids Can Be Engineered from Three Primary Germ Layers Derived Separately from Pluripotent Stem Cells

[Cell Stem Cell] Researchers developed an organoid assembly approach starting with cells from the three primary germ layers—enteric neuroglial, mesenchymal, and epithelial precursors—that were derived separately from human PSCs.

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