induced pluripotent stem cells

[Molecular Therapy-Methods & Clinical Development] Scientists derived human proximal lung organoids from patient-derived pluripotent stem cells carrying disease-causing cystic fibrosis transmembrane conductance regulator mutations.

[AgeX Therapeutics, Inc. (BusinessWire, Inc.)] AgeX Therapeutics, Inc. announced that ImStem Biotechnology, Inc. has dosed the first US multiple sclerosis patient with ImStem’s lead investigational drug candidate IMS001.

[Stem Cell Research & Therapy] The authors outline current approaches aiming to improve the beneficial outcomes of cell therapy to better grasp clinical cell transformation.

[Journal of Molecular and Cellular Cardiology] Investigators outline how to overcome hurdles in the production of functional cardiomyocytes from human iPSCs (hiPSCs-CMs) to realize the transplantation of hiPSC-CMs in patients with heart failure and introduce cutting-edge findings and perspectives for future regenerative therapy.

[Biomaterials] Researchers reported the development of a chemically defined, artificial 3D microniche for iPSCs’ growth and reliable expansion, constructed with degradable polyethyleneglycol-co-polycaprolactone and RGDfk-functionalized dendritic polyglycerol precursors according to bioorthogonal strain-promoted azide-alkyne cycloaddition by droplet-based microfluidics.

[Biochemical Society Transactions] Scientists review the state-of-the-art knowledge of compartmentalization in the cell nucleus and the relevance of this process for transcriptional regulation, particularly in PSCs.