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induced pluripotent stem cells

Direct Conversion of Cell Fate and Induced Endothelial Cells

[Circulation Journal] Researchers suggest that careful assessment of the status of converted cells using genetic and epigenetic profiling, various functional assays, and the use of multiple readouts is essential to determine successful conversion.

PCSK9 Regulates the NODAL Signaling Pathway and Cellular Proliferation in hiPSCs

[Stem Cell Reports] Proprotein convertase subtilisin kexin type 9 (PCSK9) inhibition in human iPSCs (hiPSCs) with the use of short hairpin RNA, CRISPR/cas9-mediated knockout, or endogenous PCSK9 loss-of-function mutation R104C/V114A unveiled its new role as a potential cell cycle regulator through the NODAL signaling pathway.

Intraperitoneal Administration of Human “Neo-Islets”, 3-D Organoids of Mesenchymal Stromal and Pancreatic Islet Cells, Normalizes Blood Glucose Levels in Streptozotocin-Diabetic NOD/SCID Mice: Significance for...

[PLoS One] A new “endocrine pancreas” delivered islet hormones physiologically into the hepatic portal vein. Treatment of insulin-dependent dogs with allogeneic canine Neo-Islets consistently improved glycemic control without the need for antirejection drugs.

Developmental Defects and Impaired Network Excitability in a Cerebral Organoid Model of KCNJ11 p.V59M-Related Neonatal Diabetes

[Scientific Reports] Investigators generated cerebral organoids derived from human iPSCs (hiPSCs) possessing the KCNJ11 mutation p.Val59Met (V59M) and from non-pathogenic/normal hiPSCs.

Inherent Genomic Properties Underlie the Epigenomic Heterogeneity of Human Induced Pluripotent Stem Cells

[Cell Reports] Scientists showed that seven human iPSC lines with variable germline potential exhibited substantial epigenomic heterogeneity, despite their uniform transcriptomes.

A Human iPSC-Astroglia Neurodevelopmental Model Reveals Divergent Transcriptomic Patterns in Schizophrenia

[Translational Psychiatry] Investigators used a human induced pluripotent stem cell (iPSC)-derived astrocyte model and investigated the temporal patterns of astroglia differentiation during developmental stages critical for schizophrenia using RNA sequencing.

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