induced pluripotent stem cells

[Cell Biology International] Researchers described functions of plant-derived fibroblast growth factor 2 and human serum albumin in maintenance and differentiation of human iPSCs.

[iScience] Scientists investigated DNA, RNA, epigenetics, and proteins in iPSC-derived motor neurons from patients with amyotrophic lateral sclerosis (ALS) carrying hexanucleotide expansions in C9ORF72.

[Cytotherapy] The authors provided a platform for identifying markers for predicting MSC functional capacity using partial least squares regression modeling that could be used as release criteria and guide future manufacturing strategies for mesenchymal stromal cells and other cell therapies.

[Scientific Reports] Scientists reported that human iPSC-derived retinal organoids release exosomes and microvesicles with small noncoding RNA cargo.

[Nature Communications] Researchers developed a platform of micron-scale cardiac muscle bundles to control biomechanics in arrays of thousands of purified, independently contracting cardiac muscle strips on two-dimensional elastomer substrates with far greater throughput than single cell methods.

[Journal of Virology] Scientists infected hiPSC-derived cardiomyocytes, from healthy human subjects, with SARS-CoV-2 in the absence and presence of IL-6 and IL-1β. Infection resulted in increased numbers of multinucleated cells.