induced pluripotent stem cells

[ONK Therapeutics Ltd] ONK Therapeutics Ltd announced that the US Patent and Trademark Office has granted its licensed patent that covers CISH knockout in natural killer (NK) cells, irrespective of the source of the NK cells, including, for example, human cord blood-derived and human iPSC-derived cells

[Current Biology] Researchers showed that human induced pluripotent stem cell-derived cardiomyocytes from patients with rs2229774 and who suffered doxorubicin-induced cardiotoxicity were more sensitive to doxorubicin.

[Cell Reports] Researchers showed that the transcription factor BCL11A was expressed in a subset of midbrain dopaminergic (mDA) neurons in the developing and adult murine brain and in a subpopulation of pluripotent-stem-cell-derived human mDA neurons.

[Stem Cell Reports] Researchers applied single-nuclei and single-cell transcriptomics to model interneuron development from human cortex and interneurons derived from PSCs, and provided a direct comparison of various in vitro interneuron derivation methods to determine the homogeneity achieved.

[Gene Therapy] By combining next generation whole exome sequencing and iPSC technology, the authors found that an Alu repeat inserted in exon 9 of the MAK gene resulted in a loss of normal MAK transcript and development of human autosomal recessive retinitis pigmentosa.

[Cell Stem Cell] Natural killer (NK) cells derived from uniformly engineered iPSCs, termed iADAPT, displayed metabolic features and gene expression profiles mirroring those of cytomegalovirus-induced adaptive NK cells.