induced pluripotent stem cells

[Communications Biology] Using both human induced pluripotent stem cells and mouse models, researchers found that FUS-ALS causative mutations affect the activity of two relevant RNA-binding protein with important roles in neuronal RNA metabolism: HuD/ELAVL4 and FMRP.

[Biochemical Pharmacology] The authors discuss patient-specific in vitro models of genetic diseases of the heart based on iPSCs, that address questions surrounding how different variants in the SCN5A gene produce different clinical syndromes.

[UC San Diego Health] The governing Board of the California Institute for Regenerative Medicine has approved a trio of awards, totaling approximately $4 million, to University of California San Diego School of Medicine researchers to advance studies of new stem cell-based treatments for multiple types of cancer and amyotrophic lateral sclerosis.

[Scientific Reports] Investigators established an in vitro cellular model using neurons differentiated from Down syndrome (DS) patient-derived iPSCs and isogenic euploid iPSCs. Neurons differentiated from DS patient-derived iPSCs secreted more amyloid β compared to those differentiated from the euploid iPSCs.

[Cardiovascular Research] The authors identified CARdiomyocyte Maturation-Associated lncRNA (CARMA), a conserved long non-coding RNA controlling cardiomyocyte differentiation and maturation in human ESCs.

[Scientific Reports] Researchers established an in vitro cellular model using neurons differentiated from Down syndrome patient-derived induced pluripotent stem cells (iPSCs) and isogenic euploid iPSCs.