induced pluripotent stem cells

[Nature Biomedical Engineering] Investigators reported a 3D culture system and protocol for the production of human spinal-cord-like organoids recapitulating the neurulation-like tube-forming morphogenesis of the early spinal cord.

[Cell Death Discovery] Investigators established an in vitro model of alcoholic cardiomyopathy based on human induced pluripotent stem cell-derived cardiomyocytes.

[Science Advances] The authors used genome-wide screening to identify essential regulators as well as major impediments of human primed to naïve PSC reprogramming.

[Scientific Reports] Scientists showed that the hepatic functions of hPSC-hepatocyte-like cells were facilitated by applying physiological liver temperatures during hepatic differentiation.

[Stem Cell Reports] Phospholamban (PLN) deletion in human induced pluripotent stem cell-cardiomyocytes had enhanced contractility at day 30, but proceeded to a cardiac failure phenotype at day 60, with decreased contractility, mitochondrial damage, increased reactive oxygen species production, cellular energy metabolism imbalance, and poor Ca2+ handling.

[Advanced Science] Scientists isolated extracellular vesicles (EVs) from key stages of the human induced pluripotent stem cell-cardiomyocyte differentiation and maturation, with the aim of identifying a promising cell biofactory for EV production, and pinpointed the genetic signatures of bioactive EVs.