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induced pluripotent stem cells

Developing Human Pluripotent Stem Cell-Based Cerebral Organoids with a Controllable Microglia Ratio for Modeling Brain Development and Pathology

[Stem Cell Reports] Investigators reported a new brain region-specific, microglia-containing organoid model by co-culturing human PSC-derived primitive neural progenitor cells and primitive macrophage progenitors.

Expression Dynamics of HAND1/2 in In Vitro Human Cardiomyocyte Differentiation

[Stem Cell Reports] Scientists established two triple-reporter human induced pluripotent stem cell lines that expressed HAND1mCherry, HAND2EGFP and either MYH6-driven iRFP670 or tagBFP constitutively and investigated their expression dynamics during cardiac differentiation.

Gain-of-Function Mutation in Ubiquitin-Ligase KLHL24 Causes Desmin Degradation and Dilatation in hiPSC-Derived Engineered Heart Tissues

[Journal of Clinical Investigation] Dynamically loaded engineered heart tissues (dyn-EHTs) were generated from human induced pluripotent stem cell (hiPSC)-derived cardiomyocytes from two patients and three (non)familial controls. KLHL24 RNA interference or direct desmin overexpression recovered desmin protein levels, restoring morphology and function in patient-derived dyn-EHTs.

Development of a Quantitative Prediction Algorithm for Target Organ-Specific Similarity of Human Pluripotent Stem Cell-Derived Organoids and Cells

[Nature Communications] Researchers evaluated the similarity of generate human PSC-derived organoids and cells to human organs using a constructed quantitative calculation system.

Dynamic Loading of Human Engineered Heart Tissue Enhances Contractile Function and Drives a Desmosome-Linked Disease Phenotype

[Science Translational Medicine] Researchers developed a new dynamic engineered heart tissue model that enabled them to tune preload and have unconstrained contractile shortening of >10%. For disease modeling, they used human induced pluripotent stem cell-derived cardiomyocytes from a patient with arrhythmogenic cardiomyopathy due to mutations in the desmoplakin gene.

Advanced Regenerative Medicine Strategies for Treatment of Perianal Fistula in Crohn’s Disease

[Inflammatory Bowel Diseases] Scientists focus on advanced regenerative-based methods including stem cell therapy, exosome therapy, and tissue engineering used in the treatment of perianal fistula.

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