induced pluripotent stem cells

[Journal of Bioscience and Bioengineering] Researchers evaluated changes in extracellular vesicles morphology, concentration, and miRNA and protein expression in culture supernatants during the differentiation of iPSCs into neural lineage cells, for application in regenerative medicine for Parkinson's disease.

[Genomics Proteomics & Bioinformatics] The authors provided systematic theoretical guidance for optimizing the iPSCs-derived red blood cells differentiation system, which is a useful model for simulating in vivo hematopoietic development and differentiation.

[Journal of Molecular Cell Biology] The authors introduced the most recent advances of human embryonic stem cell- or induced pluripotent stem cell-derived organoids to model 3D neuromuscular junctions.

[Cell Reports Medicine] Scientists used induced pluripotent stem cells from patients with hereditary sensory neuropathy type 1 to determine whether endogenous 1-deoxysphingolipid bases were neurotoxic, patho-mechanisms of toxicity and response to therapy.

[Scientific Reports] Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes from four healthy donors were incubated with lipopolysaccharides, TRPV1 agonist capsaicin or the antagonist capsazepine to investigate the role of transient receptor potential vanilloid 1 (TRPV1) for myocardial inflammation.

[Stem Cell Reports] Both human pluripotent stem cell-derived cardiomyocytes and adult cardiomyocytes could be productively infected by SARS-CoV-2, leading to secretion of the monocyte chemoattractant cytokine CCL2 and subsequent monocyte recruitment.