induced pluripotent stem cells

[Circulation] Human induced pluripotent stem cell derived cardiomyocytes as well as ex vivo and in vivo models of ischemia-reperfusion injury were used to test the efficacy of ASIC1a inhibitors as pre- and post-conditioning therapeutic agents.

[Experimental Health Perspectives] The authors identified a potential synergy between mutation in the high-risk autism gene encoding chromodomain helicase DNA binding protein 8 and environmental exposure to an organophosphate pesticide an iPSC-derived human 3D brain model.

[eLife] To overcome limitations and address species-specific cellular organization, investigators derived organoids from rapidly developing teleosts.

[Cardiovascular Research] The authors present the generation, development, and application of current cellular, animal and potential for bio-printed models, in the study of the pathophysiological mechanisms underlying dystrophin-linked cardiomyopathy in the direction of personalized medicine.

[Cell Reports] Scientists investigated the contribution of the X-linked intellectual disability (XLID)-associated RBMX in neuronal differentiation.Transcriptomic analysis of isogenic Shashi-XLID human iPSCs generated using CRISPR-Cas9 revealed a dysregulation of MDM4 splicing and aberrant p53 upregulation.

[Current Opinion in Genetics & Development] Transcription factor-induced reprogramming of somatic cells across lineages and to iPSCs has revealed a remarkable plasticity of differentiated cells and presents great opportunities for generating clinically relevant cell types for disease modeling and regenerative medicine.