induced pluripotent stem cells

[Analytical Chemistry] Scientists developed an impedance system to measure the change in electrical resistance of 3D HIOs depending on the integrity of the intestinal epithelial cell membrane, which can reflect functionality and maturity.

[Journal of Neuroscience Methods] Investigators cultured iPSC-derived excitatory neurons in 3D precast hydrogel plates and compared their maturation to 2D monolayer cultures.

[Nature Communications] Researchers reported the generation of an expandable, 3D branching ureteric bud (UB) organoid culture model that could be derived from primary UB progenitors from mouse and human fetal kidneys, or generated de novo from human PSCs.

[Experimental Dermatology] Investigators found that let-7c, miR-26b-5p, −29c-3p, −148a-3p, −196a-5p, −199b-5p and −374a-5p were suppressed in iPSC-derived fibroblasts in vitro and in 3D dermis-like self-assembly tissue, whereas their corresponding targets involved in cellular migration were upregulated.

[Stem Cell Reviews and Reports] Scientists discuss the common properties of cancer stem cells (CSCs) and PSCs, and highlight the potential of PSCs in cancer studies, therapeutic applications, as well as educating the immune system against CSCs.

[nan] Shoreline Biosciences, Inc. and BeiGene, Ltd. announced a worldwide collaboration to develop and commercialize a portfolio of natural killer (NK)-based cell therapeutics with Shoreline’s iPSC NK cell technology and BeiGene’s research and clinical development capabilities for different malignancies.