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induced pluripotent stem cells

Human Induced Pluripotent Stem Cells-Derived Corneal Endothelial-Like Cells Promote Corneal Transparency in a Rabbit Model of Bullous Keratopath

[Stem Cells and Development] Researchers used a modified approach to differentiate induced pluripotent stem cells into corneal endothelial-like cells (CECs). After the identification of differentiated CECs, the CECs were injected into the anterior chambers of the eyes of a rabbit model of bullous keratopathy.

Using Induced Pluripotent Stem Cells to Investigate Human Neuronal Phenotypes in 1q21.1 Deletion and Duplication Syndrome

[Molecular Psychiatry] To determine the impact of copy number variation at the 1q21.1 locus on neuronal development, researchers generated iPSCs from individuals harbouring 1q21.1 deletion or duplication and differentiated them into functional cortical neurons.

Porcine Primordial Germ Cell-Like Cells Generated from Induced Pluripotent Stem Cells under Different Culture Conditions

[Stem Cell Reviews and Reports] The authors analyzed the influence of the in vitro environment on the induction of porcine iPSCs differentiation into primordial germ cell-like cells, providing a suitable in vitro model for use in translational studies and to help answer numerous remaining questions about germ cells.

A Human Isogenic iPSC-Derived Cell Line Panel Identifies Major Regulators of Aberrant Astrocyte Proliferation in Down Syndrome

[Communications Biology] Scientists established a human isogenic cell line panel based on Down syndrome-specific iPSCs, the XIST-mediated transcriptional silencing system in trisomic chromosome 21, and genome/chromosome-editing technologies to eliminate phenotypic fluctuations caused by genetic variation.

Biological Importance of OCT Transcription Factors in Reprogramming and Development

[Experimental & Molecular Medicine] Investigators discuss the roles of the structural components of Oct proteins in reprogramming and how donor cell epigenomes endow Oct proteins with different reprogramming competences.

Induced Pluripotent Stem Cells (iPSCs) Provide a Potentially Unlimited T Cell Source for CAR-T Cell Development and Off-the-Shelf Products

[Pharmaceutical Research] Scientists discuss the progress made in induced pluripotent stem cells (iPSC)-derived T cells and provides a roadmap for the development of CAR iPSC-derived T cells and off-the-shelf T-iPSCs.

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