induced pluripotent stem cells

[Proceedings of the National Academy of Sciences of the United States of America] Scientists examined epigenome remodeling at the onset of human nuclear reprogramming by profiling human fibroblasts after fusion with murine ESCs. Efficient reprogramming of human fibroblasts to iPSCs was achieved by transduction with vectors expressing SOX2, KLF4, and inducible dnAP-1, demonstrating that dnAP-1 can substitute for exogenous human OCT4.

[Cell Reports] Researchers performed an integrated analysis of DNA methylation, chromatin accessibility, and gene expression across hundreds of human PSC samples.

[Cell Reports] Scientists reported that a common mechanism for the initiation of the erosion of X chromosome inactivation of female human PSCs depended on XIST loss but not XACT accumulation on inactive X chromosomes.

[Journal of Pharmacological and Toxicological Methods] The authors assessed similarities and differences between commercially available iPSC hepatocytes and primary human hepatocytes in preliminary assays of drug metabolism, hepatotoxicity, and drug transport.

[Stem Cell Reviews and Reports] Scientists provide an overview of promising easily accessible somatic cell sources isolated in non-invasive or minimally invasive manner such as keratinocytes, urine cells, and peripheral blood mononuclear cells used for the generation of human iPSCs derived from healthy and diseased subjects.

[BlueRock Therapeutics] BlueRock Therapeutics announced the dose administration for the first patient in a Phase I, open-label study of PSC-derived dopaminergic neurons in patients with advanced Parkinson’s disease.