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induced pluripotent stem cells

Human Stem Cells Harboring a Suicide Gene Improve the Safety and Standardization of Neural Transplants in Parkinsonian Rats

[Nature Communications] The engineered FailSafeTM hPSCs demonstrated robust ventral midbrain specification in vitro, capable of forming neural grafts upon transplantation.

Actuation Enhances Patterning in Human Neural Tube Organoids

[Nature Communications] Researchers showed that active mechanical forces increase growth and lead to enhanced patterning in an organoid model of the neural tube derived from single human pluripotent stem cells (hPSC).

Transcriptome Analysis of MBD5-Associated Neurodevelopmental Disorder (MAND) Neural Progenitor Cells Reveals Dysregulation of Autism-Associated Genes

[Scientific Reports] Researchers created neural progenitor cells (NPC) derived from individuals with chromosome 2q23.1 deletion and conducted RNA-seq to identify differentially expressed genes (DEGs) and the biological processes and pathways altered in MAND.

Cross-Platform Validation of Neurotransmitter Release Impairments in Schizophrenia Patient-Derived NRXN1-Mutant Neurons

[Proceedings of the National Academy of Sciences of the United States of America] Scientists described a multicenter effort to test the generality of this pivotal observation, using independent analyses at two laboratories of patient-derived and newly engineered human neurons with heterozygous NRXN1 deletions.

Lithium Increases Mitochondrial Respiration in iPSC-Derived Neural Precursor Cells from Lithium Responders

[Molecular Psychiatry] Researchers investigated the molecular effects ofLithium, valproate and lamotrigine treatment in induced pluripotent stem cell (iPSC)-derived neural precursor cells (NPCs) generated from three healthy controls, three affective disorder Li responsive patients and three Li non-treated patients after six hours and one week of exposure.

Identification of Bioactive Metabolites in Human iPSC-Derived Dopaminergic Neurons with PARK2 Mutation: Altered Mitochondrial and Energy Metabolism

[Stem Cell Reports] Scientists used isogenic human induced pluripotent stem cells (iPSCs) with and without PARK2 knockout to investigate the effect of parkin loss of function by comparative metabolomics supplemented with ultrastructural and functional analyses.

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