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influenza

Human Organotypic Airway and Lung Organoid Cells of Bronchiolar and Alveolar Differentiation Are Permissive to Infection by Influenza and SARS-CoV-2 Respiratory Virus

[Frontiers in Cellular and infection Microbiology] The authors established, from single biopsy specimens, a human adult stem cell-derived organoid model representing the upper respiratory airways and lungs and explored the applicability of this model to study respiratory virus infection.

Revelation Biosciences, Inc. Announces Enrollment and Dosing Complete for Phase IIb Viral Challenge Study to Assess Efficacy of Intranasal REVTx 99 for the Prevention...

[Revelation Biosciences, Inc.] Revelation Biosciences Inc. announced that it has completed enrollment and dosing in Phase IIb viral challenge study to evaluate the efficacy of intranasal REVTx-99 for the preventive treatment of H3N2 influenza infection in healthy humans.

The RNA Helicase DHX16 Recognizes Specific Viral RNA to Trigger RIG-I-Dependent Innate Antiviral Immunity

[Cell Reports] Scientists identified the RNA helicase DHX16 as a potential pattern recognition receptor. Silencing of DHX16 in cells and in vivo diminished IFN-I responses against influenza virus.

HLA-A*11:01-Restricted CD8+ T Cell Immunity against Influenza A and Influenza B Viruses in Indigenous and Non-Indigenous People

[PLoS Pathogens] Investigators embarked on an epitope discovery study to define a CD8+ T cell landscape for HLA-A*11:01-expressing Indigenous and non-Indigenous Australian people.

H5N1 Infection Impairs the Alveolar Epithelial Barrier through Intercellular Junction Proteins via Itch-Mediated Proteasomal Degradation

[Communications Biology] Researchers suggested that H5N1 virus infection impaired the alveolar epithelial barrier by downregulating the expression of intercellular junction proteins at the posttranslational level.

Interferon-γ Promotes Monocyte-Mediated Lung Injury during Influenza Infection

[Cell Reports] The authors identified an interferon-γ-regulated subset of monocytes, CCR2+ monocytes, as a driver of lung damage during influenza A virus infection.

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