insulin producing cells

[Artificial Organs] In vitro studies showed, wharton’s jelly-derived-MSCs that differentiated in the 3D culture have strong properties of insulin-producing cells such as islet-like cells.

[Cellular and Molecular Life Sciences] Transcriptional co-activator with PDZ-binding motif (TAZ) defect caused structural changes in the pancreas, particularly islet cell shrinkage, and decreased insulin production and β-cell markers expression, leading to hyperglycemia.

[Nature Metabolism] In vitro expression of Mycl provoked active replication in islet cells, even in those from aged mice.

[Stem Cell Reviews and Reports] Researchers compared the therapeutic efficacy of mesenchymal stem cells derived from amniotic membrane and umbilical cord of the same donor in the alleviation of type 2 diabetes mellitus symptoms and explored the underlying mechanisms.

[Cancers] Researchers showed that inhibition of RAC1 activation attenuated pluripotency marker expression and self-renewal ability, while depletion of RAC1b dramatically enhanced stemness features and clonogenic potential.

[Heliyon] Scientists investigated the effect of insulin-producing cells derived from adipose tissue MSCs on diabetic-induced impairments as the abnormalities of testicular tissues, oxidative stress of testes, and defects of spermatogenesis.