Comparative Analysis of the Therapeutic Effects of Amniotic Membrane and Umbilical Cord Derived Mesenchymal Stem Cells for the Treatment of Type 2 Diabetes

Researchers compared the therapeutic efficacy of mesenchymal stem cells derived from amniotic membrane and umbilical cord of the same donor in the alleviation of type 2 diabetes mellitus symptoms and explored the underlying mechanisms.
[Stem Cell Reviews and Reports]
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Activation of a Ductal-to-Endocrine Transdifferentiation Transcriptional Program in the Pancreatic Cancer Cell Line PANC-1 Is Controlled by RAC1 and RAC1b through Antagonistic Regulation of Stemness Factors

Researchers showed that inhibition of RAC1 activation attenuated pluripotency marker expression and self-renewal ability, while depletion of RAC1b dramatically enhanced stemness features and clonogenic potential.
[Cancers]
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Impact of Insulin Producing Cells Derived from Adipose Tissue Mesenchymal Stem Cells on Testicular Dysfunction of Diabetic Rats

Scientists investigated the effect of insulin-producing cells derived from adipose tissue MSCs on diabetic-induced impairments as the abnormalities of testicular tissues, oxidative stress of testes, and defects of spermatogenesis.
[Heliyon]
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Pancreatic β-Cell Development and Regeneration

Scientists describe the development and function of β-cells the emerging concept of heterogeneity within insulin-producing cells, and the potential of other cell types to assume β-cell functionality via transdifferentiation.
[Cold Spring Harbor Perspectives in Biology]
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New hPSC SOX9 and INS Reporter Cell Lines Facilitate the Observation and Optimization of Differentiation into Insulin-Producing Cells

For the purpose of easy monitoring of differentiation efficiencies into pancreatic progenitors and insulin-producing cells, scientists generated new reporter lines by knocking in a P2A-H-2Kk-F2A-GFP2 reporter gene into the SOX9-locus and a P2A-mCherry reporter gene into the INS-locus mediated by CRISPR/CAS9-technology.
[Stem Cell Reviews and Reports]
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Process Parameter Development for the Scaled Generation of Stem Cell-Derived Pancreatic Endocrine Cells

Scientists discuss the potential of both stem cell-derived pancreatic progenitors and more matured insulin-producing cells to treat diabetes.
[Stem Cells Translational Medicine]
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Pancreatic Extracellular Matrix/Alginate Hydrogels Provide a Supportive Microenvironment for Insulin-Producing Cells

Hydrogel prepared with alginate and the pancreatic extracellular matrix was assessed for the beneficial outcomes on encapsulated insulin-producing cells.
[ACS Biomaterials Science & Engineering]
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Design Considerations for Macroencapsulation Devices for Stem Cell Derived Islets for the Treatment of Type I Diabetes

The design considerations and functional requirements of macroencapsulation systems are reviewed, specifically for stem-cell derived islets, highlighting distinct design parameters.
[Advanced Science]
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Tailored Generation of Insulin Producing Cells from Canine Mesenchymal Stem Cells Derived from Bone Marrow and Adipose Tissue

Researchers investigated insulin-producing cell generation from two practical canine MSCs, canine bone marrow-derived MSC, and canine adipose-derived MSCs.
[Scientific Reports]
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Scrt1, a Transcriptional Regulator of β-Cell Proliferation Identified by Differential Chromatin Accessibility during Islet Maturation

Scrt1 expression was controlled by the transcriptional repressor RE-1 silencing transcription factor (REST) and was increased in an in vitro reprogramming system of pancreatic exocrine cells to β-like cells.
[Scientific Reports]
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Glucagon Blockade Restores Functional β-Cell Mass in Type 1 Diabetic Mice and Enhances Function of Human Islets

The authors evaluated the potential for a monoclonal antibody antagonist of the glucagon receptor to maintain glucose homeostasis in type 1 diabetic rodents.
[Proceedings of the National Academy of Sciences of the United States of America]
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