Comparative Analysis of the Therapeutic Effects of Amniotic Membrane and Umbilical Cord Derived Mesenchymal Stem Cells for the Treatment of Type 2 Diabetes

Researchers compared the therapeutic efficacy of mesenchymal stem cells derived from amniotic membrane and umbilical cord of the same donor in the alleviation of type 2 diabetes mellitus symptoms and explored the underlying mechanisms.
[Stem Cell Reviews and Reports]
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Inter-Organ Crosstalk in Pancreatic Islet Function and Pathology

Scientists discuss recent advances in inter-organ communication from the metabolic, immune, and neural system to pancreatic islets, their biological implication in normal pancreas endocrine function, as well as their role in the adaptive responses of islet to nutrition-induced stress.
[Febs Letters]
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Grainyhead 1 Acts as a Drug-Inducible Conserved Transcriptional Regulator Linked to Insulin Signaling and Lifespan

Researchers showed that increased expression of the transcription factor Grainyhead 1 promoted lifespan and pathogen resistance in Caenorhabditis elegans.
[Nature Communications]
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Organization and Dynamics of the Cortical Complexes Controlling Insulin Secretion in β-Cells

Researchers showed that insulin secretion sites also contain non-neuronal proteins LL5β and KANK1, which in migrating cells organize exocytotic machinery in the vicinity of integrin-based adhesions.
[Journal of Cell Science]
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ATP Is an Essential Autocrine Factor for Pancreatic β-Cell Signaling and Insulin Secretion

Scientists monitored changes of the intracellular Ca2+ concentration as an immediate read-out for insulin secretion in live cell experiments.
[Physiological Reports]
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Clenbuterol Exerts Antidiabetic Activity through Metabolic Reprogramming of Skeletal Muscle Cells

To elucidate the underlying cellular and molecular mechanisms, researchers chronically treated wild-type mice and several newly developed mutant mouse strains with clenbuterol, a selective β2-adrenergic receptor agonist.
[Nature Communications]
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Using Adipose-Derived Mesenchymal Stem Cells to Fight the Metabolic Complications of Obesity: Where Do We Stand?

Adipose-derived MSC transplantation may offer a potential therapeutic approach for the treatment of metabolic complications of obesity, but randomized controlled trials are required to establish their safety and efficacy in humans prior to routine clinical use.
[Obesity Reviews]
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The Cancer-Testis lncRNA Lnc-CTHCC Promotes Hepatocellular Carcinogenesis by Binding hnRNP K and Activating YAP1 Transcription

The authors discovered a conserved cancer-testis (CT)-long non-coding RNAs (lncRNA), named lnc-CTHCC, which was highly expressed in the testes and hepatocellular carcinoma.
[Nature Cancer]
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Possibility of Adiponectin Use to Improve Islet Transplantation Outcomes

In in vitro assessment, released insulin at high glucose stimulation, insulin content, and expressions of vascular endothelial growth factor and integrin β1 were improved in adiponectin-treated islets.
[Scientific Reports]
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Intestinal Gpr17 Deficiency Improves Glucose Metabolism by Promoting GLP-1 Secretion

Scientists showed that Gpr17, an orphan G protein-coupled receptors, was co-expressed in glucagon-like peptide-1 (GLP-1)-expressing EECs in human and rodent intestinal epithelium.
[Cell Reports]
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Hsa_circ_0003258 Promotes Prostate Cancer Metastasis by Complexing with IGF2BP3 and Sponging miR-653-5p

Hsa_circ_0003258 physically binded to insulin like growth factor 2 mRNA binding protein 3 (IGF2BP3) in the cytoplasm and enhanced HDAC4 mRNA stability, in which it activated ERK signaling pathway, then triggered epithelial mesenchymal transformation programming and finally accelerated the metastasis of prostate cancer.
[Molecular Cancer]
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