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insulin

Cardioprotective Effect of Extracellular Vesicles Derived from Ticagrelor-Pretreated Cardiomyocyte on Hyperglycemic Cardiomyocytes through Alleviation of Oxidative and Endoplasmic Reticulum Stress

[Scientific Reports] Scientists investigated the anti-oxidative and cardioprotective effect of extracellular vesicles derived from ticagrelor-pretreated cardiomyocytes under diabetes mellitus conditions.

IL-37 Isoform D Acts as an Inhibitor of Soluble ST2 to Boost Type 2 Immune Homeostasis in White Adipose Tissue

[Cell Death Discovery] IL-37 isoform D transgene amplified ST2+ immune cells, promoted M2 macrophage polarization and type 2 cytokine secretion in white adipose tissue that mediated beiging and inflammation resolution, thereby increasing energy expenditure, reducing obesity and insulin resistance in high-fat diet-fed mice.

AVM Biotechnology Awarded $1.6 Million Phase II SBIR Grant to Study AVM0703’s Potential to Reverse Type 1 Diabetes

[AVM Biotechnology, LLC (Business Wire)] AVM Biotechnology, LLC, announced that it has been awarded a Phase II Small Business Innovation Research (SBIR) grant. This $1.6 million award from the National Institute of Diabetes and Digestive Kidney Disease will allow the company to pursue additional research in the use of AVM0703 as a monotherapy and combination therapy to reverse recent onset and established Type 1 Diabetes.

Fractyl Health Announces FDA IDE Approval to Begin Revitalize-2 Pivotal Study Designed for Patients with Type 2 Diabetes (T2D) Who Are Not Yet on...

[Fractyl Health, Inc.] Fractyl Health announced that the company has received approval from the FDA for an Investigational Device Exemption (IDE) to begin its Revitalize-2 pivotal study.

Effects of 1,5-Anhydro-D-Glucitol on Insulin Secretion Both in In Vitro and Ex Vivo Pancreatic Preparations

[Journal of Pharmacological Sciences] The authors assessed the effects of short-term 1,5-anhydro-D-glucitol stimulation on insulin secretion in both ex vivo and in INS-1E rat-derived cells in vitro.

More than Meets the Islet: Aligning Nutrient and Paracrine Inputs with Hormone Secretion in Health and Disease

[American Journal of Physiology-Endocrinology and Metabolism] Investigators critically discuss the contributions of external, intrinsic, and paracrine factors in pancreatic β-, α-, and δ-cell secretion across the full spectrum of physiological (i.e., fasting and fed) and pathophysiological (gluco- and lipotoxicity; diabetes) environments.

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