insulin

[Communications Biology] Investigators reported the development of a high-throughput RNAi screening approach to identify upstream pathways that regulated adult human β cell quiescence and demonstrated in a screen of the GPCRome that silencing G-protein coupled receptor 3 (GPR3) led to human pancreatic β cell proliferation.

[Nature Communications] Scientists found that the γ-cell population was heterogeneous, with subsets of cells producing another hormone in addition to pancreatic polypeptide (Ppy).

[Nature Reviews Nephrology] In self-limiting inflammation, the evolving inflammatory response is coupled to distinct processes that promote the resolution of inflammation and restore homeostasis.

[Autophagy] Scientists found that adipose-specific expression of BECN1F121A was sufficient to improve systemic insulin sensitivity without negatively affecting pancreatic insulin storage.

[Nature Communications] In isolated pancreatic acinar cells, insulin induced Akt-mediated phosphorylation of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (PFKFB2) which upregulated glycolysis thereby preventing POA-induced ATP depletion.

[Environmental Science and Pollution Research] Scientists showed that mono-(2-ethylhexyl) phthalate (MEHP) decreases the cell viability of pancreatic beta-cell (INS-1 cells) in a concentration-dependent manner and induces pyroptosis at 400 μM.