insulin

[ACS Biomaterials Science & Engineering] Hydrogel prepared with alginate and the pancreatic extracellular matrix was assessed for the beneficial outcomes on encapsulated insulin-producing cells.

[Molecular and Cellular Endocrinology] As the effects of growth hormone-releasing hormone and its agonists have not been fully elucidated in the beta cell, scientists proposed to investigate them by evaluating the role of the growth-hormone-releasing hormone agonist, MR-409, in cells under endoplasmic reticulum stress.

[Nature Reviews Gastroenterology & Hepatology] Scientists review cross-sectional studies on dietary habits of patients with nonalcoholic fatty liver disease and randomized controlled trials on the effects of altering dietary macronutrients on intrahepatic triglyceride.

[Blood] Expression of YBX1 was significantly upregulated in myeloid leukemia cells, and deletion of YBX1 dramatically induced apoptosis and promoted differentiation coupled with reduced proliferation and impaired leukemic capacity of primary human and mouse acute myeloid leukemia cells in vitro and in vivo.

[Cell Death & Disease] Researchers investigated the roles of IGF-1 signaling during agonist-induced cardiac fibrosis and evaluated the molecular mechanisms in cultured cardiac fibroblasts. They found severe interstitial fibrosis in angiotensin II/phenylephrine infused myofibroblast-specific IGF-1R knockout mice compared to the wild-type mice.

[Stem Cell Research & Therapy] Scientists report a comprehensive comparison of human MSCs derived from umbilical cord Wharton’s jelly (UC-MSCs), dental pulp, and adipose tissue on the treatment of glucose and lipid metabolic disorders in type II diabetic mice.