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insulin
Cell Therapy News
Effects of Stem Cells from Inducible Brown Adipose Tissue on Diet-Induced Obesity in Mice
[Scientific Reports] Researchers isolated and characterized adipose-derived mesenchymal stem cells from the visceral adipose tissue surrounding a pheochromocytoma, a model of inducible brown adipose tissue in humans.
Intestinal Cell News
FTO Downregulation Mediated by Hypoxia Facilitates Colorectal Cancer Metastasis
[Oncogene] Researchers found that fat mass and obesity-associated (FTO) protein levels, but not RNA levels, were downregulated in colorectal cancer (CRC) tissues. Reduced FTO protein expression was correlated with a high recurrence rate and poor prognosis in resectable CRC patients.
Pancreatic Cell News
Fetuin-A Excess Expression Amplifies Lipid Induced Apoptosis and β-Cell Damage
[Journal of Cellular Physiology] Scientists validated the effect of fetuin-A release and lipid induced apoptosis in mouse insulinoma cell line MIN6.
Pancreatic Cell News
SNAP-Tag-Enabled Super-Resolution Imaging Reveals Constitutive and Agonist-Dependent Trafficking of GPR56 in Pancreatic β-Cells
[Molecular Metabolism] Researchers introduced SNAPf-tag into the N-terminal segment of GPR56 to enable monitoring of GPR56 cellular activity in situ.
Pancreatic Cell News
MafA, NeuroD1, and HNF1β Synergistically Activate Slc2a2 (Glut2) Gene in β-Cells
[Journal of Molecular Endocrinology] Scientists found that an evolutionarily conserved region located approximately 40 kbp downstream of the transcription start site of Slc2a2 functioned as an active enhancer in the MIN6 β-cell line.
Mesenchymal Cell News
Effects of Stem Cells from Inducible Brown Adipose Tissue on Diet-Induced Obesity in Mice
[Scientific Reports] Scientists isolated and characterized adipose-derived MSCs from the visceral adipose tissue surrounding a pheochromocytoma, a model of inducible brown adipose tissue in humans.