insulin

[eLife] The authors explore the potential pathogenic metabolic mechanisms that could underly both severe acute COVID-19 and post-acute sequelae of CoV-2, and then consider how these might be targeted for future therapeutic approaches.

[Stem Cell Research & Therapy] Human umbilical cord-derived MSCs infusions improved systemic metabolic homeostasis and alleviated insulin resistance in epididymal adipose tissue but elicited no change in weight.

[Communications Biology] To discriminate the role of PFKFB3 from HIF1α in vivo, scientists generated mice with conditional β-cell specific disruption of the Pfkfb3 gene on a human islet pancreatic polypeptide background and a high-fat diet.

[Diabetologia] Mouse lines that expressed a gain-of-function mutation in the γ1 AMP-activated protein kinase (AMPK) subunit D316a were generated to examine the effects of chronic AMPK stimulation in the whole body, or selectively in the beta cell.

[Endocrinology] Researchers discovered that growth differentiation factor 15 (GDF15) promoted endoplasmic reticulum (ER) stress-induced beta cell apoptosis and that the downregulation of GDF15 has beneficial effects on beta cell survival in diabetes.

[JCI Insight] Scientists found that Notch activation in postnatal β cells impaired glucose-stimulated insulin secretion and glucose intolerance, but also observed a remnant glucose intolerance after doxycycline withdrawal and cessation of Notch activity, associated with a marked disruption of normal islet architecture.