Tag results:
insulin
Pancreatic Cell News
Functional, Metabolic, and Transcriptional Maturation of Human Pancreatic Islets Derived from Stem Cells
[Nature Biotechnology] Investigators generated functionally mature stem-cell-derived islets using an optimized protocol and benchmarked them comprehensively against primary adult islets.
Pancreatic Cell News
Pancreatic Islet Cryopreservation by Vitrification Achieves High Viability, Function, Recovery, and Clinical Scalability for Transplantation
[Nature Medicine] Researchers achieved high recovery, viability, function and scalability in mouse, porcine, human, and human stem cell-derived beta cell islets by comprehensive optimization of cryoprotectant agent composition, and methods for vitrification and rewarming.
Pancreatic Cell News
TAZ Promotes PDX1-Mediated Insulinogenesis
[Cellular and Molecular Life Sciences] Transcriptional co-activator with PDZ-binding motif (TAZ) defect caused structural changes in the pancreas, particularly islet cell shrinkage, and decreased insulin production and β-cell markers expression, leading to hyperglycemia.
Pancreatic Cell News
Increased Expression of Viral Sensor MDA5 in Pancreatic Islets and in Hormone-Negative Endocrine Cells in Recent Onset Type 1 Diabetic Donors
[Frontiers in Immunology] The authors used multiplex immunofluorescence imaging analysis to characterize MDA5 expression and distribution in pancreatic tissues obtained from 22 organ donors.
Pancreatic Cell News
Recent Developments in Biomarkers for Diagnosis and Screening of Type 2 Diabetes Mellitus
[Current Diabetes Reports] Investigators focus on the recent development of new clinically validated and novel biomarkers as well as the methods that represent cost-effective alternatives for screening and early diagnosis of type 2 diabetes mellitus.
Pancreatic Cell News
Transcriptional Control of Pancreatic β-Cell Identity and Plasticity during the Pathogenesis of Type 2 Diabetes
[Journal of Genetics and Genomics] The authors summarize the roles and underlying mechanisms of transcription factors in the maintenance of β-cell identity under physiological and type 2 diabetic conditions.