interleukin-4

[Science Translational Medicine] The authors characterized blood samples collected from 51 preterm infants longitudinally at five time points, 20 healthy term infants at birth and age 3 to 16 weeks, and five healthy adults, and observed strong associations between type 2 immune polarization in circulating CD3+CD4+ T cells and cardiopulmonary illness, with odds ratios up to 24.

[Scientific Reports] Enforced expression of Lyve1 in RAW264.7 cells resulted in increased mRNA expression of matrix metalloproteinase 2 (Mmp2), Mmp9, and VEGF A. Lyve1-expressing macrophages promoted the migration and tube formation of HUVECs.

[Cell Biochemistry and Biophysics] The authors investigated the effect of fatty acid binding protein 4 (FABP4) on lipogenesis in human skeletal muscle cells stimulated by Interleukin-4 and explored the mechanistic basis.

[Cancer Cell] The authors showed that oncogenic KrasG12D increased IL-33 expression in PDAC cells, which recruited and activated TH2 and innate lymphoid cells 2 cells.

[NPJ Regenerative Medicine] Researchers developed an “off-the-shelf” adipose ECM biomaterial from allograft human tissue, applying physical and chemical processing methods to remove lipids and create an injectable matrix that mimicked the properties of lipoaspirate.

[Hypertension] The role of the CCL5 and IL4 in kidney fibrosis was studied by administration of the CCL5 receptor antagonist maraviroc or by injections of an anti-IL4 neutralizing antibody.