Neutrophil Gelatinase-Associated Lipocalin From Macrophages Plays a Critical Role in Renal Fibrosis Via the CCL5 (Chemokine Ligand 5)-Th2 Cells-IL4 (Interleukin 4) Pathway

The role of the CCL5 and IL4 in kidney fibrosis was studied by administration of the CCL5 receptor antagonist maraviroc or by injections of an anti-IL4 neutralizing antibody.
[Hypertension]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Lactate Supports a Metabolic-Epigenetic Link in Macrophage Polarization

Investigators reported that interleukin-4 –induced M0 → M2 macrophage polarization was accompanied by interchangeable glucose- or lactate-dependent tricarboxylic acid cycle metabolism that directly drove histone acetylation, M2 gene transcription, and functional immune suppression.
[Science Advances]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Differences in In Vitro Microglial Accumulation of the Energy Metabolism Tracers [18F]FDG and [18F]BCPP-EF during LPS- and IL4 Stimulation

Scientists evaluated lipopolysaccharide (LPS)- and interleukin 4 (IL4)-stimulated microglial uptake of [14C]2DG and [18F]BCPP-EF to give a new insight into the hypothesis that different uptake of [18F]FDG and [18F]BCPP-EF could be ascribed to the different metabolic pathways activated during microglial activation.
[Scientific Reports]
[zotpress userid=’7753456′ items=’D2H65WQM’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Mechanisms Underlying Divergent Responses of Genetically Distinct Macrophages to IL-4

The authors evaluated effects of >50 million single-nucleotide polymorphisms and short insertions/deletions provided by five inbred strains of mice on the responses of macrophages to interleukin-4 (IL-4), a cytokine that plays pleiotropic roles in immunity and tissue homeostasis.
[Science Advances]
[zotpress userid=” items=’5P2KNIZ5′ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Induction of the Apoptosis, Degranulation and IL-13 Production of Human Basophils by Butyrate and Propionate via Suppression of Histone Deacetylation

Investigators elucidated the function of short chain fatty acids on human basophils. Human basophils were purified from healthy donors by flow cytometric sorting.
[British Journal of Immunology]
[zotpress userid=” items=’UI9ND885′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Dual Vaccination against IL-4 and IL-13 Protects against Chronic Allergic Asthma in Mice

Investigators developed conjugate vaccines against mouse IL-4 and IL-13, and demonstrated their prophylactic and therapeutic efficacy in reducing IgE levels, AHR, eosinophilia and mucus production in mouse models of asthma analyzed up to 15 weeks after initial vaccination.
[Nature Communications]
[zotpress userid=” items=’HCIR3YUF’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

IL4 Promotes Phagocytosis of Murine Leukemia Cells Counteracted by CD47 Upregulation

Scientists investigated whether interleukin 4 (IL4) had antileukemic activity via immune-mediated mechanisms in an in vivo murine model of acute myeloid leukemia driven by the MLL–AF9 fusion gene.
[Haematologica]
[zotpress userid=’6445218′ items=’BFL4VI68′ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Alternative Activation of Human Macrophages Enhances Tissue Factor Expression and Production of Extracellular Vesicles

To understand if polarization of macrophages can lead to a procoagulant macrophage subset researchers polarized human monocyte derived macrophages to a proinflammatory and an alternative activation state.
[Haematologica]
[zotpress userid=’6445218′ items=’QBK54Y3H’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Human Amniotic Membrane-Mesenchymal Stem Cells-Conditioned Medium Reduces Inflammatory Factors and Fibrosis in Ovalbumin-Induced Asthma in Mice

Investigators examined the effects of human amniotic membrane MSCs‐conditioned medium on ovalbumin (OVA)‐induced asthma. 48 hours after the last challenge, serum and bronchoalveolar lavage fluid samples were collected and used for evaluation of inflammatory factors and cells, respectively.
[Experimental Physiology]
[zotpress userid=’6445212′ items=’UTYI3B3C’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Regulatory T Cell-Derived TGF-β1 Controls Multiple Checkpoints Governing Allergy and Autoimmunity

The mechanisms by which regulatory T (Treg) cells differentially control allergic and autoimmune responses remain unclear. Researchers showed that Treg cells in food allergy had decreased expression of transforming growth factor beta 1 (TGF-β1) because of interleukin-4- and signal transducer and activator of transciription-6-dependent inhibition of Tgfb1 transcription.
[Immunity]
[zotpress userid=’6630899′ items=’HEYT48MX’ style=’apa’ cite=’yes’]
AbstractGraphical Abstract
Bookmark

No account yet? Register

Share

Cancer Immunotherapy via Targeted TGF-β Signalling Blockade in TH Cells

Following the finding that transforming growth factor-β (TGF-β) suppresses T helper 2 (TH2)-cell-mediated cancer immunity, scientists showed that blocking TGF-β signalling in CD4+ T cells remodels the tumour microenvironment and restrains cancer progression.
[Nature]
[zotpress userid=’6630899′ items=’KZMFKNQZ’ style=’apa’ cite=’yes’]
AbstractPress Release
Bookmark

No account yet? Register

Share
Share