intestinal cells

[Acta Pharmacologica Sinica] Alcohol dehydrogenase 1C (ADH1C) was first identified as a target gene closely associated with the development of CRC by the comprehensive application of transcriptomics, proteomics, metabonomics and in silico analysis.

[Immunity] Investigators identified Sh2d6 as a signature marker for CD45+ Tuft-2 cells. Depletion of Tuft-2 cells resulted in susceptibility to bacterial infection.

[Digestive Diseases and Sciences] The authors provide novel insights into the role of chemical chaperone unfolded protein response modulators to modify endoplasmic reticulum (ER) stress levels in the pathogenesis of inflammatory bowel disease.

[Scientific Reports] Investigators used selective small molecule inhibitors of monoacylglycerol acyltransferase 2 (MGAT2) and MGAT3 to determine the contributions of these enzymes to triacylglycerol production in liver cells.

[Nature Biomedical Engineering] The authors showed that druggable biological targets and small-molecule regulators of intestinal stem cell differentiation could be identified via multiplexed phenotypic screening using thousands of miniaturized organoid models of intestinal stem cell differentiation into Paneth cells.

[Stem Cells Translational Medicine] Scientists discuss recent advances in understanding the mechanisms that regulate stem cell regeneration.