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intestinal epithelial cells

Epithelial Gasdermin D Shapes the Host-Microbial Interface by Driving Mucus Layer Formation

[Science Immunology] Scientists linked epithelial Gasdermin D to the secretory granule exocytotic pathway and highlighted its physiological nonpyroptotic role in shaping mucosal homeostasis in the gut.

2′-Fucosyllactose Promotes Lactobacillus rhamnosus KLDS 8001 to Repair LPS-Induced Damage in Caco-2 Cells

[Journal of Food Biochemistry] Researchers investigated the effect of 2'-fucosyllactose on the repair of monolayer barrier damage in Caco-2 cells by Lactobacillus rhamnosus KLDS 8001 (KLDS 8001).

Salmonella pSLT-Encoded Effector SpvB Promotes RIPK3-Dependent Necroptosis in Intestinal Epithelial Cells

[Cell Death Discovery] Scientists demonstrated that SpvB promoted necroptosis of intestinal epithelial cells and contributed to the destruction of the intestinal barrier during Salmonella infection.

Cranberry Proanthocyanidin and Its Microbial Metabolite 3,4-Dihydroxyphenylacetic Acid, but Not 3-(4-Hydroxyphenyl)-Propionic Acid, Partially Reverse Pro-inflammatory microRNA Responses in Human Intestinal Epithelial Cells

[Molecular Nutrition & Food Research] The authors investigated the effects of a cranberry proanthocyanidin-rich extract and two of its gut microbial metabolites, 3,4-dihydroxyphenylacetic acid and 3-(4-hydroxyphenyl)-propionic acid, on intestinal epithelial cells microRNA expression and their downstream pathways at homeostasis and in inflammatory conditions.

m6A Modifications Regulate Intestinal Immunity and Rotavirus Infection

[eLife] Investigators uncovered a novel antiviral function of N6-methyladenosine (m6A) modification during rotavirus infection in small bowel intestinal epithelial cells.

Omega-3 Fatty Acids Impair miR-1-3p-Dependent Notch3 Down-Regulation and Alleviate Sepsis-Induced Intestinal Injury

[Molecular Medicine] Researchers explored if omega-3 fatty acids could affect sepsis-induced intestinal injury with the involvement of the microRNA-1-3p/Notch3-Smad axis.

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