intestinal epithelial cells

[mBio] Investigators developed a method for live-cell imaging of microbial infection dynamics on human adult stem cell-derived intestinal epithelial cell layers.

[Journal of Clinical Investigation] Researchers showed that TNF-independent intestinal epithelial cells death after A20 and Abin-1 deletion was rescued by germ-free derivation or deletion of MyD88, while deletion of Trif provided only partial protection.

[Oncogene] BEST4 is a member of the bestrophin protein family that plays a critical role in human intestinal epithelial cells. Scientists investigated the role and clinical significance of BEST4 in CRC.

[Cell Reports] Investigators developed a chronic-injury model in human colonoid monolayers by repeated rounds of air-liquid interface and submerged culture.

[Cell Reports] The authors found that CDC42 loss initiated in the intestinal stem cell caused a drastic hyperproliferation of transit amplifying cells and disrupted epithelial polarity.

[Journal of Cellular Physiology] Scientists characterized that Lactobacillus plantarum activated the farnesoid X receptor – fibroblast growth factor 15 signaling in intestinal epithelial cells and hence promoted DNA-damage repair.