intestinal epithelial cells

[Journal of Experimental Medicine] Researchers revealed that in addition to its known regulatory properties in preventing immune hyperactivity, gut epithelial IL-27 confered barrier immunity by inducing a specific intraepithelial lymphocyte subset and further suggested that IL-27 produced by different cell types played distinct roles in maintaining intestinal homeostasis.

[Cell Death & Disease] Through unbiased kinome RNAi and drug repurposing screens scientists identified JAK1/2 kinases as the principal and nonredundant drivers of the synergistic killing of human intestinal epithelial cells by IFN-γ/TNF-α.

[Science Immunology] To decipher immune recognition of human adenoviruse (HAdV) infection and determine new targets for immune-mediated control, researchers used an HAdV infection 3D organoid system, based on primary human intestinal epithelial cells.

[Nature Communications] Scientists performed an integrative genomic profiling of 163 pediatric liver tumors based on the data acquired from a cohort study. DNA methylation profiling revealed that classical hepatoblastomas were characterized by the specific hypomethylated enhancers, which were enriched with binding sites for ASCL2, a regulatory transcription factor for definitive endoderm in Wnt-pathway.

[Cell Death & Disease] How transketolase (TKT) functions in the intestinal epithelium remains to be elucidated. To address this question, researchers specifically deleted TKT in intestinal epithelial cells.

[Science] Researchers showed that low-density lipoprotein receptor—related protein 1 mediated cell surface binding and the endocytosis of serum amyloid A-retinol complexes in cultured cells.