intestinal stem cells

[Trends in Molecular Medicine] Scientists present recent studies on probiotics and postbiotics in the context of novel discovery tools, such as organoids and organoid-based platforms, and nontransformed preclinical models, that can be generated from intestinal stem cells.

[Proceedings of the National Academy of Sciences of the United States of America] From an RNA interference (RNAi) screen in adult Drosophila intestinal stem cells (ISCs), researchers identified a factor, Yun, required for proliferation of normal and transformed ISCs.

[Trends in Cancer] The authors highlight the importance of stem cell/niche interactions in developing and established colorectal cancer and discuss how these can be modulated to develop novel preventive and therapeutic interventions.

[Oncogene] The authors investigated the impact of oncogenic transformation and the microenvironment on tumor cell invasion using genetically engineered organoids as colorectal cancer models.

[Cell Reports] Investigators developed a chronic-injury model in human colonoid monolayers by repeated rounds of air-liquid interface and submerged culture.

[Cell Reports] The authors found that CDC42 loss initiated in the intestinal stem cell caused a drastic hyperproliferation of transit amplifying cells and disrupted epithelial polarity.