Tag results:
intestinal stem cells
Intestinal Cell News
Robust Differentiation of Human Enteroendocrine Cells from Intestinal Stem Cells
[Nature Communications] Investigator employed small molecule targeting of the endocannabinoid receptor signaling pathway, JNK, and FOXO1, known to mediate endodermal development and/or hormone production, together with directed differentiation of human ISCs from the duodenum and rectum.
Intestinal Cell News
ID2 Controls Differentiation of Enteroendocrine Cells in Mouse Small Intestine
[Acta Physiologica] To assess the functions of ID2 in the adult mouse small intestine, investigators used single-cell RNA sequencing, genetically modified mice, and organoid assays.
Intestinal Cell News
Ionizing Radiation Alters Organoid Forming Potential and Replenishment Rate in a Dose/Dose-Rate Dependent Manner
[Journal of Radiation Research] Researchers assessed the response to radiation dose and dose-rate by measuring both organoid-forming potential and the percentage of stem cells in the crypts.
Organoid News
MLL1 Is Required for Maintenance of Intestinal Stem Cells
[PLoS Genetics] Loss of mixed lineage leukemia 1 (MLL1) was accompanied by loss of intestinal stem cells and a differentiation bias towards the secretory lineage with increased numbers and enlargement of goblet cells.
Intestinal Cell News
Smooth Muscle-Specific MMP17 (MT4-MMP) Regulates the Intestinal Stem Cell Niche and Regeneration after Damage
[Nature Communications] Scientists showed that smooth muscle cells might be the dominant suppliers of BMP antagonists, which are niche factors essential for intestinal stem cell maintenance.
Extracellular Matrix News
Synthetic Dynamic Hydrogels Promote Degradation-Independent In Vitro Organogenesis
[Nature Materials] Investigators reported a family of synthetic hydrogels that promoted extensive organoid morphogenesis through dynamic rearrangements mediated by reversible hydrogen bonding.