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intestinal stem cells

Robust Differentiation of Human Enteroendocrine Cells from Intestinal Stem Cells

[Nature Communications] Investigator employed small molecule targeting of the endocannabinoid receptor signaling pathway, JNK, and FOXO1, known to mediate endodermal development and/or hormone production, together with directed differentiation of human ISCs from the duodenum and rectum.

ID2 Controls Differentiation of Enteroendocrine Cells in Mouse Small Intestine

[Acta Physiologica] To assess the functions of ID2 in the adult mouse small intestine, investigators used single-cell RNA sequencing, genetically modified mice, and organoid assays.

Ionizing Radiation Alters Organoid Forming Potential and Replenishment Rate in a Dose/Dose-Rate Dependent Manner

[Journal of Radiation Research] Researchers assessed the response to radiation dose and dose-rate by measuring both organoid-forming potential and the percentage of stem cells in the crypts.

MLL1 Is Required for Maintenance of Intestinal Stem Cells

[PLoS Genetics] Loss of mixed lineage leukemia 1 (MLL1) was accompanied by loss of intestinal stem cells and a differentiation bias towards the secretory lineage with increased numbers and enlargement of goblet cells.

Smooth Muscle-Specific MMP17 (MT4-MMP) Regulates the Intestinal Stem Cell Niche and Regeneration after Damage

[Nature Communications] Scientists showed that smooth muscle cells might be the dominant suppliers of BMP antagonists, which are niche factors essential for intestinal stem cell maintenance.

Synthetic Dynamic Hydrogels Promote Degradation-Independent In Vitro Organogenesis

[Nature Materials] Investigators reported a family of synthetic hydrogels that promoted extensive organoid morphogenesis through dynamic rearrangements mediated by reversible hydrogen bonding.

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